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Patient-Driven Discovery, Therapeutic Targeting, and Post-Clinical Validation of a Novel AKT1 Fusion-Driven Cancer.
Slotkin EK, Diolaiti D, Shukla NN, Dela Cruz FS, Clark JJ, Gundem G, Yellapantula VD, Levine MF, You D, Ma P, Pachhal S, Ibanez Sanchez G, Benayed R, Jungbluth AA, Smyth LM, Mauguen A, Gushterova I, Ding H, Spraggon L, Darnell R, Califano A, Ladanyi M, Papaemmanuil E, Kung AL, Hyman DM, Roberts SS. Slotkin EK, et al. Among authors: clark jj. Cancer Discov. 2019 May;9(5):605-616. doi: 10.1158/2159-8290.CD-18-0953. Epub 2019 Mar 15. Cancer Discov. 2019. PMID: 30877085 Free PMC article.
Protective effect and molecular mechanisms of human non-neutralizing cross-reactive spike antibodies elicited by SARS-CoV-2 mRNA vaccination.
Clark JJ, Hoxie I, Adelsberg DC, Sapse IA, Andreata-Santos R, Yong JS, Amanat F, Tcheou J, Raskin A, Singh G, González-Domínguez I, Edgar JE, Bournazos S, Sun W, Carreño JM, Simon V, Ellebedy AH, Bajic G, Krammer F. Clark JJ, et al. Cell Rep. 2024 Nov 26;43(11):114922. doi: 10.1016/j.celrep.2024.114922. Epub 2024 Nov 5. Cell Rep. 2024. PMID: 39504245 Free article.
Pulmonary SARS-CoV-2 infection leads to para-infectious immune activation in the brain.
Dunai C, Hetherington C, Boardman SA, Clark JJ, Sharma P, Subramaniam K, Tharmaratnam K, Needham EJ, Williams R, Huang Y, Wood GK, Collie C, Fower A, Fox H, Ellul MA, Held M, Egbe FN, Griffiths M, Solomon T, Breen G, Kipar A, Cavanagh J, Irani SR, Vincent A, Stewart JP, Taams LS, Menon DK, Michael BD. Dunai C, et al. Among authors: clark jj. Front Immunol. 2024 Oct 14;15:1440324. doi: 10.3389/fimmu.2024.1440324. eCollection 2024. Front Immunol. 2024. PMID: 39474424 Free PMC article.
A recombinant N2 neuraminidase-based CpG 1018® adjuvanted vaccine provides protection against challenge with heterologous influenza viruses in mice and hamsters.
Hoxie I, Vasilev K, Clark JJ, Bushfield K, Francis B, Loganathan M, Campbell JD, Yu D, Guan L, Gu C, Fan S, Tompkins SM, Neumann G, Kawaoka Y, Krammer F. Hoxie I, et al. Among authors: clark jj. Vaccine. 2024 Oct 24;42(24):126269. doi: 10.1016/j.vaccine.2024.126269. Epub 2024 Sep 5. Vaccine. 2024. PMID: 39241354 Free article.
Dissecting human monoclonal antibody responses from mRNA- and protein-based XBB.1.5 COVID-19 monovalent vaccines.
Fantin RF, Clark JJ, Cohn H, Jaiswal D, Bozarth B, Civljak A, Rao V, Lobo I, Nardulli JR, Srivastava K, Yong J, Andreata-Santos R, Bushfield K, Lee ES, Singh G; PVI Study Group; Kleinstein SH, Krammer F, Simon V, Bajic G, Coelho CH. Fantin RF, et al. Among authors: clark jj. bioRxiv [Preprint]. 2024 Jul 16:2024.07.15.602781. doi: 10.1101/2024.07.15.602781. bioRxiv. 2024. PMID: 39071292 Free PMC article. Preprint.
Delayed Mucosal Antiviral Responses Despite Robust Peripheral Inflammation in Fatal COVID-19.
Sidhu JK, Siggins MK, Liew F, Russell CD, Uruchurtu ASS, Davis C, Turtle L, Moore SC, Hardwick HE, Oosthuyzen W, Thomson EC, Semple MG, Baillie JK, Openshaw PJM, Thwaites RS; ISARIC4C investigators. Sidhu JK, et al. J Infect Dis. 2024 Jul 25;230(1):e17-e29. doi: 10.1093/infdis/jiad590. J Infect Dis. 2024. PMID: 39052740 Free PMC article.
Sequential Infection with Influenza A Virus Followed by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Leads to More Severe Disease and Encephalitis in a Mouse Model of COVID-19.
Clark JJ, Penrice-Randal R, Sharma P, Dong X, Pennington SH, Marriott AE, Colombo S, Davidson A, Kavanagh Williamson M, Matthews DA, Turtle L, Prince T, Hughes GL, Patterson EI, Shawli G, Mega DF, Subramaniam K, Sharp J, Turner JD, Biagini GA, Owen A, Kipar A, Hiscox JA, Stewart JP. Clark JJ, et al. Viruses. 2024 May 28;16(6):863. doi: 10.3390/v16060863. Viruses. 2024. PMID: 38932155 Free PMC article.
The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection.
Fernández JJ, Marín A, Rosales R, Penrice-Randal R, Mlcochova P, Alvarez Y, Villalón-Letelier F, Yildiz S, Pérez E, Rathnasinghe R, Cupic A, Kehrer T, Uccellini MB, Alonso S, Martínez F, McGovern BL, Clark JJ, Sharma P, Bayón Y, Alonso A, Albrecht RA, White KM, Schotsaert M, Miorin L, Stewart JP, Hiscox JA, Gupta RK, Irigoyen N, García-Sastre A, Crespo MS, Fernández N. Fernández JJ, et al. Among authors: clark jj. Biochim Biophys Acta Mol Basis Dis. 2024 Jun;1870(5):167193. doi: 10.1016/j.bbadis.2024.167193. Epub 2024 Apr 20. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 38648902
239 results