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Direct Inhibition of MmpL3 by Novel Antitubercular Compounds.
Li W, Stevens CM, Pandya AN, Darzynkiewicz Z, Bhattarai P, Tong W, Gonzalez-Juarrero M, North EJ, Zgurskaya HI, Jackson M. Li W, et al. Among authors: stevens cm. ACS Infect Dis. 2019 Jun 14;5(6):1001-1012. doi: 10.1021/acsinfecdis.9b00048. Epub 2019 Mar 28. ACS Infect Dis. 2019. PMID: 30882198 Free PMC article.
Proton transfer activity of the reconstituted Mycobacterium tuberculosis MmpL3 is modulated by substrate mimics and inhibitors.
Stevens CM, Babii SO, Pandya AN, Li W, Li Y, Mehla J, Scott R, Hegde P, Prathipati PK, Acharya A, Liu J, Gumbart JC, North J, Jackson M, Zgurskaya HI. Stevens CM, et al. Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2113963119. doi: 10.1073/pnas.2113963119. Epub 2022 Jul 19. Proc Natl Acad Sci U S A. 2022. PMID: 35858440 Free PMC article.
Microbiological profile, preclinical pharmacokinetics and efficacy of CRS0393, a novel antimycobacterial agent targeting MmpL3.
Ochsner UA, De Groote MA, Jarvis TC, Liu H, Youmans T, Hoang T, Ribble W, Day J, Li W, Pearce C, Walz A, Panthi CM, Rimal B, Stevens CM, Zgurskaya HI, Jackson M, Ordway D, Gonzalez-Juarrero M, Sun X, Lamichhane G, Mason C. Ochsner UA, et al. Among authors: stevens cm. Tuberculosis (Edinb). 2023 Jan;138:102288. doi: 10.1016/j.tube.2022.102288. Epub 2022 Nov 29. Tuberculosis (Edinb). 2023. PMID: 36470124 Free PMC article.
Structural Determinants of Indole-2-carboxamides: Identification of Lead Acetamides with Pan Antimycobacterial Activity.
Bhattarai P, Hegde P, Li W, Prathipati PK, Stevens CM, Yang L, Zhou H, Pandya A, Cunningham K, Grissom J, Roman Sotelo M, Sowards M, Calisto L, Destache CJ, Rocha-Sanchez S, Gumbart JC, Zgurskaya HI, Jackson M, North EJ. Bhattarai P, et al. Among authors: stevens cm. J Med Chem. 2023 Jan 12;66(1):170-187. doi: 10.1021/acs.jmedchem.2c00352. Epub 2022 Dec 23. J Med Chem. 2023. PMID: 36563291 Free PMC article.
112 results