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A single-center, open-label positron emission tomography study to evaluate brivaracetam and levetiracetam synaptic vesicle glycoprotein 2A binding in healthy volunteers.
Finnema SJ, Rossano S, Naganawa M, Henry S, Gao H, Pracitto R, Maguire RP, Mercier J, Kervyn S, Nicolas JM, Klitgaard H, DeBruyn S, Otoul C, Martin P, Muglia P, Matuskey D, Nabulsi NB, Huang Y, Kaminski RM, Hannestad J, Stockis A, Carson RE. Finnema SJ, et al. Among authors: hannestad j. Epilepsia. 2019 May;60(5):958-967. doi: 10.1111/epi.14701. Epub 2019 Mar 29. Epilepsia. 2019. PMID: 30924924 Free PMC article. Clinical Trial.
Brivaracetam, a selective high-affinity synaptic vesicle protein 2A (SV2A) ligand with preclinical evidence of high brain permeability and fast onset of action.
Nicolas JM, Hannestad J, Holden D, Kervyn S, Nabulsi N, Tytgat D, Huang Y, Chanteux H, Staelens L, Matagne A, Mathy FX, Mercier J, Stockis A, Carson RE, Klitgaard H. Nicolas JM, et al. Among authors: hannestad j. Epilepsia. 2016 Feb;57(2):201-9. doi: 10.1111/epi.13267. Epub 2015 Dec 10. Epilepsia. 2016. PMID: 26663401 Free article.
Imaging synaptic density in the living human brain.
Finnema SJ, Nabulsi NB, Eid T, Detyniecki K, Lin SF, Chen MK, Dhaher R, Matuskey D, Baum E, Holden D, Spencer DD, Mercier J, Hannestad J, Huang Y, Carson RE. Finnema SJ, et al. Among authors: hannestad j. Sci Transl Med. 2016 Jul 20;8(348):348ra96. doi: 10.1126/scitranslmed.aaf6667. Sci Transl Med. 2016. PMID: 27440727 Clinical Trial.
Kinetic evaluation and test-retest reproducibility of [11C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans.
Finnema SJ, Nabulsi NB, Mercier J, Lin SF, Chen MK, Matuskey D, Gallezot JD, Henry S, Hannestad J, Huang Y, Carson RE. Finnema SJ, et al. Among authors: hannestad j. J Cereb Blood Flow Metab. 2018 Nov;38(11):2041-2052. doi: 10.1177/0271678X17724947. Epub 2017 Aug 9. J Cereb Blood Flow Metab. 2018. PMID: 28792356 Free PMC article.
Imaging robust microglial activation after lipopolysaccharide administration in humans with PET.
Sandiego CM, Gallezot JD, Pittman B, Nabulsi N, Lim K, Lin SF, Matuskey D, Lee JY, O'Connor KC, Huang Y, Carson RE, Hannestad J, Cosgrove KP. Sandiego CM, et al. Among authors: hannestad j. Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12468-73. doi: 10.1073/pnas.1511003112. Epub 2015 Sep 18. Proc Natl Acad Sci U S A. 2015. PMID: 26385967 Free PMC article.
Synthesis and Preclinical Evaluation of 11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain.
Nabulsi NB, Mercier J, Holden D, Carré S, Najafzadeh S, Vandergeten MC, Lin SF, Deo A, Price N, Wood M, Lara-Jaime T, Montel F, Laruelle M, Carson RE, Hannestad J, Huang Y. Nabulsi NB, et al. Among authors: hannestad j. J Nucl Med. 2016 May;57(5):777-84. doi: 10.2967/jnumed.115.168179. Epub 2016 Feb 4. J Nucl Med. 2016. PMID: 26848175 Free article.
Padsevonil randomized Phase IIa trial in treatment-resistant focal epilepsy: a translational approach.
Muglia P, Hannestad J, Brandt C, DeBruyn S, Germani M, Lacroix B, Majoie M, Otoul C, Sciberras D, Steinhoff BJ, Van Laere K, Van Paesschen W, Webster E, Kaminski RM, Werhahn KJ, Toledo M. Muglia P, et al. Among authors: hannestad j. Brain Commun. 2020 Nov 2;2(2):fcaa183. doi: 10.1093/braincomms/fcaa183. eCollection 2020. Brain Commun. 2020. PMID: 33241213 Free PMC article.
78 results