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Using fMRI connectivity to define a treatment-resistant form of post-traumatic stress disorder.
Etkin A, Maron-Katz A, Wu W, Fonzo GA, Huemer J, Vértes PE, Patenaude B, Richiardi J, Goodkind MS, Keller CJ, Ramos-Cejudo J, Zaiko YV, Peng KK, Shpigel E, Longwell P, Toll RT, Thompson A, Zack S, Gonzalez B, Edelstein R, Chen J, Akingbade I, Weiss E, Hart R, Mann S, Durkin K, Baete SH, Boada FE, Genfi A, Autea J, Newman J, Oathes DJ, Lindley SE, Abu-Amara D, Arnow BA, Crossley N, Hallmayer J, Fossati S, Rothbaum BO, Marmar CR, Bullmore ET, O'Hara R. Etkin A, et al. Sci Transl Med. 2019 Apr 3;11(486):eaal3236. doi: 10.1126/scitranslmed.aal3236. Sci Transl Med. 2019. PMID: 30944165 Free PMC article. Clinical Trial.
A genome-wide identified risk variant for PTSD is a methylation quantitative trait locus and confers decreased cortical activation to fearful faces.
Almli LM, Stevens JS, Smith AK, Kilaru V, Meng Q, Flory J, Abu-Amara D, Hammamieh R, Yang R, Mercer KB, Binder EB, Bradley B, Hamilton S, Jett M, Yehuda R, Marmar CR, Ressler KJ. Almli LM, et al. Am J Med Genet B Neuropsychiatr Genet. 2015 Jul;168B(5):327-36. doi: 10.1002/ajmg.b.32315. Epub 2015 May 18. Am J Med Genet B Neuropsychiatr Genet. 2015. PMID: 25988933 Free PMC article.
Mitochondrial DNA copy number is reduced in male combat veterans with PTSD.
Bersani FS, Morley C, Lindqvist D, Epel ES, Picard M, Yehuda R, Flory J, Bierer LM, Makotkine I, Abu-Amara D, Coy M, Reus VI, Lin J, Blackburn EH, Marmar C, Wolkowitz OM, Mellon SH. Bersani FS, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2016 Jan 4;64:10-7. doi: 10.1016/j.pnpbp.2015.06.012. Epub 2015 Jun 26. Prog Neuropsychopharmacol Biol Psychiatry. 2016. PMID: 26120081
A population of atypical CD56(-)CD16(+) natural killer cells is expanded in PTSD and is associated with symptom severity.
Bersani FS, Wolkowitz OM, Milush JM, Sinclair E, Eppling L, Aschbacher K, Lindqvist D, Yehuda R, Flory J, Bierer LM, Matokine I, Abu-Amara D, Reus VI, Coy M, Hough CM, Marmar CR, Mellon SH. Bersani FS, et al. Brain Behav Immun. 2016 Aug;56:264-70. doi: 10.1016/j.bbi.2016.03.021. Epub 2016 Mar 26. Brain Behav Immun. 2016. PMID: 27025668
38 results