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Page 1
Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma.
Mack SC, Singh I, Wang X, Hirsch R, Wu Q, Villagomez R, Bernatchez JA, Zhu Z, Gimple RC, Kim LJY, Morton A, Lai S, Qiu Z, Prager BC, Bertrand KC, Mah C, Zhou W, Lee C, Barnett GH, Vogelbaum MA, Sloan AE, Chavez L, Bao S, Scacheri PC, Siqueira-Neto JL, Lin CY, Rich JN. Mack SC, et al. Among authors: kim ljy. J Exp Med. 2019 May 6;216(5):1071-1090. doi: 10.1084/jem.20190196. Epub 2019 Apr 4. J Exp Med. 2019. PMID: 30948495 Free PMC article.
CDC20 maintains tumor initiating cells.
Xie Q, Wu Q, Mack SC, Yang K, Kim L, Hubert CG, Flavahan WA, Chu C, Bao S, Rich JN. Xie Q, et al. Oncotarget. 2015 May 30;6(15):13241-54. doi: 10.18632/oncotarget.3676. Oncotarget. 2015. PMID: 25938542 Free PMC article.
Purine synthesis promotes maintenance of brain tumor initiating cells in glioma.
Wang X, Yang K, Xie Q, Wu Q, Mack SC, Shi Y, Kim LJY, Prager BC, Flavahan WA, Liu X, Singer M, Hubert CG, Miller TE, Zhou W, Huang Z, Fang X, Regev A, Suvà ML, Hwang TH, Locasale JW, Bao S, Rich JN. Wang X, et al. Among authors: kim ljy. Nat Neurosci. 2017 May;20(5):661-673. doi: 10.1038/nn.4537. Epub 2017 Mar 27. Nat Neurosci. 2017. PMID: 28346452 Free PMC article.
Nicotinamide metabolism regulates glioblastoma stem cell maintenance.
Jung J, Kim LJ, Wang X, Wu Q, Sanvoranart T, Hubert CG, Prager BC, Wallace LC, Jin X, Mack SC, Rich JN. Jung J, et al. JCI Insight. 2017 May 18;2(10):e90019. doi: 10.1172/jci.insight.90019. eCollection 2017 May 18. JCI Insight. 2017. PMID: 28515364 Free PMC article.
Transcription elongation factors represent in vivo cancer dependencies in glioblastoma.
Miller TE, Liau BB, Wallace LC, Morton AR, Xie Q, Dixit D, Factor DC, Kim LJY, Morrow JJ, Wu Q, Mack SC, Hubert CG, Gillespie SM, Flavahan WA, Hoffmann T, Thummalapalli R, Hemann MT, Paddison PJ, Horbinski CM, Zuber J, Scacheri PC, Bernstein BE, Tesar PJ, Rich JN. Miller TE, et al. Among authors: kim ljy. Nature. 2017 Jul 20;547(7663):355-359. doi: 10.1038/nature23000. Epub 2017 Jul 5. Nature. 2017. PMID: 28678782 Free PMC article.
MYC-Regulated Mevalonate Metabolism Maintains Brain Tumor-Initiating Cells.
Wang X, Huang Z, Wu Q, Prager BC, Mack SC, Yang K, Kim LJY, Gimple RC, Shi Y, Lai S, Xie Q, Miller TE, Hubert CG, Song A, Dong Z, Zhou W, Fang X, Zhu Z, Mahadev V, Bao S, Rich JN. Wang X, et al. Among authors: kim ljy. Cancer Res. 2017 Sep 15;77(18):4947-4960. doi: 10.1158/0008-5472.CAN-17-0114. Epub 2017 Jul 20. Cancer Res. 2017. PMID: 28729418 Free PMC article.
Targeting glioma stem cells through combined BMI1 and EZH2 inhibition.
Jin X, Kim LJY, Wu Q, Wallace LC, Prager BC, Sanvoranart T, Gimple RC, Wang X, Mack SC, Miller TE, Huang P, Valentim CL, Zhou QG, Barnholtz-Sloan JS, Bao S, Sloan AE, Rich JN. Jin X, et al. Among authors: kim ljy. Nat Med. 2017 Nov;23(11):1352-1361. doi: 10.1038/nm.4415. Epub 2017 Oct 9. Nat Med. 2017. PMID: 29035367 Free PMC article.
Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling.
Mack SC, Pajtler KW, Chavez L, Okonechnikov K, Bertrand KC, Wang X, Erkek S, Federation A, Song A, Lee C, Wang X, McDonald L, Morrow JJ, Saiakhova A, Sin-Chan P, Wu Q, Michaelraj KA, Miller TE, Hubert CG, Ryzhova M, Garzia L, Donovan L, Dombrowski S, Factor DC, Luu B, Valentim CLL, Gimple RC, Morton A, Kim L, Prager BC, Lee JJY, Wu X, Zuccaro J, Thompson Y, Holgado BL, Reimand J, Ke SQ, Tropper A, Lai S, Vijayarajah S, Doan S, Mahadev V, Miñan AF, Gröbner SN, Lienhard M, Zapatka M, Huang Z, Aldape KD, Carcaboso AM, Houghton PJ, Keir ST, Milde T, Witt H, Li Y, Li CJ, Bian XW, Jones DTW, Scott I, Singh SK, Huang A, Dirks PB, Bouffet E, Bradner JE, Ramaswamy V, Jabado N, Rutka JT, Northcott PA, Lupien M, Lichter P, Korshunov A, Scacheri PC, Pfister SM, Kool M, Taylor MD, Rich JN. Mack SC, et al. Nature. 2018 Jan 4;553(7686):101-105. doi: 10.1038/nature25169. Epub 2017 Dec 20. Nature. 2018. PMID: 29258295 Free PMC article.
35 results