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Page 1
WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
Chan EM, Shibue T, McFarland JM, Gaeta B, Ghandi M, Dumont N, Gonzalez A, McPartlan JS, Li T, Zhang Y, Bin Liu J, Lazaro JB, Gu P, Piett CG, Apffel A, Ali SO, Deasy R, Keskula P, Ng RWS, Roberts EA, Reznichenko E, Leung L, Alimova M, Schenone M, Islam M, Maruvka YE, Liu Y, Roper J, Raghavan S, Giannakis M, Tseng YY, Nagel ZD, D'Andrea A, Root DE, Boehm JS, Getz G, Chang S, Golub TR, Tsherniak A, Vazquez F, Bass AJ. Chan EM, et al. Among authors: mcpartlan js. Nature. 2019 Apr;568(7753):551-556. doi: 10.1038/s41586-019-1102-x. Epub 2019 Apr 10. Nature. 2019. PMID: 30971823 Free PMC article.
Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose.
Chahal JS, Khan OF, Cooper CL, McPartlan JS, Tsosie JK, Tilley LD, Sidik SM, Lourido S, Langer R, Bavari S, Ploegh HL, Anderson DG. Chahal JS, et al. Among authors: mcpartlan js. Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):E4133-42. doi: 10.1073/pnas.1600299113. Epub 2016 Jul 5. Proc Natl Acad Sci U S A. 2016. PMID: 27382155 Free PMC article.
LILRB3 (ILT5) is a myeloid cell checkpoint that elicits profound immunomodulation.
Yeboah M, Papagregoriou C, Jones DC, Chan HTC, Hu G, McPartlan JS, Schiött T, Mattson U, Mockridge CI, Tornberg UC, Hambe B, Ljungars A, Mattsson M, Tews I, Glennie MJ, Thirdborough SM, Trowsdale J, Frendeus B, Chen J, Cragg MS, Roghanian A. Yeboah M, et al. Among authors: mcpartlan js. JCI Insight. 2020 Sep 1;5(18):e141593. doi: 10.1172/jci.insight.141593. JCI Insight. 2020. PMID: 32870822 Free PMC article.
Route of self-amplifying mRNA vaccination modulates the establishment of pulmonary resident memory CD8 and CD4 T cells.
Künzli M, O'Flanagan SD, LaRue M, Talukder P, Dileepan T, Stolley JM, Soerens AG, Quarnstrom CF, Wijeyesinghe S, Ye Y, McPartlan JS, Mitchell JS, Mandl CW, Vile R, Jenkins MK, Ahmed R, Vezys V, Chahal JS, Masopust D. Künzli M, et al. Among authors: mcpartlan js. Sci Immunol. 2022 Dec 9;7(78):eadd3075. doi: 10.1126/sciimmunol.add3075. Epub 2022 Dec 2. Sci Immunol. 2022. PMID: 36459542 Free PMC article.