Brough D - Search Results

1

Cathelicidin is a "fire alarm", generating protective NLRP3-dependent airway epithelial cell inflammatory responses during infection with Pseudomonas aeruginosa.

McHugh BJ, Wang R, Li HN, Beaumont PE, Kells R, Stevens H, Young L, Rossi AG, Gray RD, Dorin JR, Gwyer Findlay EL, Brough D, Davidson DJ. McHugh BJ, et al. Among authors: brough d. PLoS Pathog. 2019 Apr 12;15(4):e1007694. doi: 10.1371/journal.ppat.1007694. eCollection 2019 Apr. PLoS Pathog. 2019. PMID: 30978238 Free PMC article.

2

Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages.

Luheshi NM, Giles JA, Lopez-Castejon G, Brough D. Luheshi NM, et al. Among authors: brough d. Eur J Immunol. 2012 Mar;42(3):716-25. doi: 10.1002/eji.201142079. Epub 2011 Dec 27. Eur J Immunol. 2012. PMID: 22105559 Free PMC article.

3

Potassium efflux fires the canon: Potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathways.

Rivers-Auty J, Brough D. Rivers-Auty J, et al. Among authors: brough d. Eur J Immunol. 2015 Oct;45(10):2758-61. doi: 10.1002/eji.201545958. Epub 2015 Sep 21. Eur J Immunol. 2015. PMID: 26332156 Free article. Review.

4

Salmonella typhimurium-induced IL-1 release from primary human monocytes requires NLRP3 and can occur in the absence of pyroptosis.

Diamond CE, Leong KWK, Vacca M, Rivers-Auty J, Brough D, Mortellaro A. Diamond CE, et al. Among authors: brough d. Sci Rep. 2017 Jul 31;7(1):6861. doi: 10.1038/s41598-017-07081-3. Sci Rep. 2017. PMID: 28761045 Free PMC article.

5

Design, Synthesis and Evaluation of Oxazaborine Inhibitors of the NLRP3 Inflammasome.

Baldwin AG, Tapia VS, Swanton T, White CS, Beswick JA, Brough D, Freeman S. Baldwin AG, et al. Among authors: brough d. ChemMedChem. 2018 Feb 20;13(4):312-320. doi: 10.1002/cmdc.201700731. Epub 2018 Feb 5. ChemMedChem. 2018. PMID: 29331080 Free PMC article.

6

Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses.

Redondo-Castro E, Faust D, Fox S, Baldwin AG, Osborne S, Haley MJ, Karran E, Nuthall H, Atkinson PJ, Dawson LA, Routledge C, Allan SM, Freeman S, Brownlees J, Brough D. Redondo-Castro E, et al. Among authors: brough d. Sci Rep. 2018 Apr 4;8(1):5667. doi: 10.1038/s41598-018-24029-3. Sci Rep. 2018. PMID: 29618797 Free PMC article.

7

Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming.

Green JP, Yu S, Martín-Sánchez F, Pelegrin P, Lopez-Castejon G, Lawrence CB, Brough D. Green JP, et al. Among authors: brough d. Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):E9371-E9380. doi: 10.1073/pnas.1812744115. Epub 2018 Sep 19. Proc Natl Acad Sci U S A. 2018. PMID: 30232264 Free PMC article.

8

Inflammasome-Independent Role for NLRP3 in Controlling Innate Antihelminth Immunity and Tissue Repair in the Lung.

Chenery AL, Alhallaf R, Agha Z, Ajendra J, Parkinson JE, Cooper MM, Chan BHK, Eichenberger RM, Dent LA, Robertson AAB, Kupz A, Brough D, Loukas A, Sutherland TE, Allen JE, Giacomin PR. Chenery AL, et al. Among authors: brough d. J Immunol. 2019 Nov 15;203(10):2724-2734. doi: 10.4049/jimmunol.1900640. Epub 2019 Oct 4. J Immunol. 2019. PMID: 31586037 Free PMC article.

9

Hallmarks of NLRP3 inflammasome activation are observed in organotypic hippocampal slice culture.

Hoyle C, Redondo-Castro E, Cook J, Tzeng TC, Allan SM, Brough D, Lemarchand E. Hoyle C, et al. Among authors: brough d. Immunology. 2020 Sep;161(1):39-52. doi: 10.1111/imm.13221. Epub 2020 Jun 22. Immunology. 2020. PMID: 32445196 Free PMC article.

10

Mechanisms of NLRP3 priming in inflammaging and age related diseases.

Gritsenko A, Green JP, Brough D, Lopez-Castejon G. Gritsenko A, et al. Among authors: brough d. Cytokine Growth Factor Rev. 2020 Oct;55:15-25. doi: 10.1016/j.cytogfr.2020.08.003. Epub 2020 Aug 24. Cytokine Growth Factor Rev. 2020. PMID: 32883606 Free PMC article. Review.

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