Lacal JC - Search Results

1

Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production.

Sanchez-Lopez E, Zhong Z, Stubelius A, Sweeney SR, Booshehri LM, Antonucci L, Liu-Bryan R, Lodi A, Terkeltaub R, Lacal JC, Murphy AN, Hoffman HM, Tiziani S, Guma M, Karin M. Sanchez-Lopez E, et al. Among authors: lacal jc. Cell Metab. 2019 Jun 4;29(6):1350-1362.e7. doi: 10.1016/j.cmet.2019.03.011. Epub 2019 Apr 11. Cell Metab. 2019. PMID: 30982734 Free PMC article.

2

Choline kinase inhibition in rheumatoid arthritis.

Guma M, Sanchez-Lopez E, Lodi A, Garcia-Carbonell R, Tiziani S, Karin M, Lacal JC, Firestein GS. Guma M, et al. Among authors: lacal jc. Ann Rheum Dis. 2015 Jul;74(7):1399-407. doi: 10.1136/annrheumdis-2014-205696. Epub 2014 Oct 1. Ann Rheum Dis. 2015. PMID: 25274633 Free PMC article.

3

Lights and shadows of proteomic technologies for the study of protein species including isoforms, splicing variants and protein post-translational modifications.

Casado-Vela J, Cebrián A, Gómez del Pulgar MT, Sánchez-López E, Vilaseca M, Menchén L, Diema C, Sellés-Marchart S, Martínez-Esteso MJ, Yubero N, Bru-Martínez R, Lacal JC. Casado-Vela J, et al. Among authors: lacal jc. Proteomics. 2011 Feb;11(4):590-603. doi: 10.1002/pmic.201000287. Epub 2011 Jan 13. Proteomics. 2011. PMID: 21229583 Review.

4

Acid ceramidase as a chemotherapeutic target to overcome resistance to the antitumoral effect of choline kinase α inhibition.

Ramírez de Molina A, de la Cueva A, Machado-Pinilla R, Rodriguez-Fanjul V, Gomez del Pulgar T, Cebrian A, Perona R, Lacal JC. Ramírez de Molina A, et al. Among authors: lacal jc. Curr Cancer Drug Targets. 2012 Jul;12(6):617-24. doi: 10.2174/156800912801784811. Curr Cancer Drug Targets. 2012. PMID: 22515519

5

Antiplasmodial activity and mechanism of action of RSM-932A, a promising synergistic inhibitor of Plasmodium falciparum choline kinase.

Zimmerman T, Moneriz C, Diez A, Bautista JM, Gómez Del Pulgar T, Cebrián A, Lacal JC. Zimmerman T, et al. Among authors: lacal jc. Antimicrob Agents Chemother. 2013 Dec;57(12):5878-88. doi: 10.1128/AAC.00920-13. Epub 2013 Sep 16. Antimicrob Agents Chemother. 2013. PMID: 24041883 Free PMC article.

6

Choline kinase as a link connecting phospholipid metabolism and cell cycle regulation: implications in cancer therapy.

Ramírez de Molina A, Gallego-Ortega D, Sarmentero-Estrada J, Lagares D, Gómez Del Pulgar T, Bandrés E, García-Foncillas J, Lacal JC. Ramírez de Molina A, et al. Among authors: lacal jc. Int J Biochem Cell Biol. 2008;40(9):1753-63. doi: 10.1016/j.biocel.2008.01.013. Epub 2008 Jan 19. Int J Biochem Cell Biol. 2008. PMID: 18296102

7

Inhibition of choline kinase renders a highly selective cytotoxic effect in tumour cells through a mitochondrial independent mechanism.

Rodríguez-González A, Ramírez de Molina A, Bañez-Coronel M, Megias D, Lacal JC. Rodríguez-González A, et al. Among authors: lacal jc. Int J Oncol. 2005 Apr;26(4):999-1008. Int J Oncol. 2005. PMID: 15753995

8

Choline Kinase Alpha (CHKα) as a Therapeutic Target in Pancreatic Ductal Adenocarcinoma: Expression, Predictive Value, and Sensitivity to Inhibitors.

Mazarico JM, Sánchez-Arévalo Lobo VJ, Favicchio R, Greenhalf W, Costello E, Carrillo-de Santa Pau E, Marqués M, Lacal JC, Aboagye E, Real FX. Mazarico JM, et al. Among authors: lacal jc. Mol Cancer Ther. 2016 Feb;15(2):323-33. doi: 10.1158/1535-7163.MCT-15-0214. Epub 2016 Jan 14. Mol Cancer Ther. 2016. PMID: 26769123

9

Phospholipase D and choline kinase: their role in cancer development and their potential as drug targets.

Rodríguez-González A, Ramírez de Molina A, Benítez-Rajal J, Lacal JC. Rodríguez-González A, et al. Among authors: lacal jc. Prog Cell Cycle Res. 2003;5:191-201. Prog Cell Cycle Res. 2003. PMID: 14593713 Review.

10

Combined 5-FU and ChoKα inhibitors as a new alternative therapy of colorectal cancer: evidence in human tumor-derived cell lines and mouse xenografts.

de la Cueva A, Ramírez de Molina A, Alvarez-Ayerza N, Ramos MA, Cebrián A, Del Pulgar TG, Lacal JC. de la Cueva A, et al. Among authors: lacal jc. PLoS One. 2013 Jun 10;8(6):e64961. doi: 10.1371/journal.pone.0064961. Print 2013. PLoS One. 2013. PMID: 23762272 Free PMC article.

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