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Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders.
Gurney ME, Nugent RA, Mo X, Sindac JA, Hagen TJ, Fox D 3rd, O'Donnell JM, Zhang C, Xu Y, Zhang HT, Groppi VE, Bailie M, White RE, Romero DL, Vellekoop AS, Walker JR, Surman MD, Zhu L, Campbell RF. Gurney ME, et al. Among authors: mo x. J Med Chem. 2019 May 23;62(10):4884-4901. doi: 10.1021/acs.jmedchem.9b00193. Epub 2019 Apr 23. J Med Chem. 2019. PMID: 31013090 Free PMC article.
Discovery of triazines as selective PDE4B versus PDE4D inhibitors.
Hagen TJ, Mo X, Burgin AB, Fox D 3rd, Zhang Z, Gurney ME. Hagen TJ, et al. Among authors: mo x. Bioorg Med Chem Lett. 2014 Aug 15;24(16):4031-4. doi: 10.1016/j.bmcl.2014.06.002. Epub 2014 Jun 12. Bioorg Med Chem Lett. 2014. PMID: 24998378 Free PMC article.
Discovery, Radiolabeling, and Evaluation of Subtype-Selective Inhibitors for Positron Emission Tomography Imaging of Brain Phosphodiesterase-4D.
Wakabayashi Y, Telu S, Dick RM, Fujita M, Ooms M, Morse CL, Liow JS, Hong JS, Gladding RL, Manly LS, Zoghbi SS, Mo X, D'Amato EC, Sindac JA, Nugent RA, Marron BE, Gurney ME, Innis RB, Pike VW. Wakabayashi Y, et al. Among authors: mo x. ACS Chem Neurosci. 2020 May 6;11(9):1311-1323. doi: 10.1021/acschemneuro.0c00077. Epub 2020 Apr 8. ACS Chem Neurosci. 2020. PMID: 32212718 Free PMC article.
3,054 results