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Page 1
Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders.
Gurney ME, Nugent RA, Mo X, Sindac JA, Hagen TJ, Fox D 3rd, O'Donnell JM, Zhang C, Xu Y, Zhang HT, Groppi VE, Bailie M, White RE, Romero DL, Vellekoop AS, Walker JR, Surman MD, Zhu L, Campbell RF. Gurney ME, et al. Among authors: surman md. J Med Chem. 2019 May 23;62(10):4884-4901. doi: 10.1021/acs.jmedchem.9b00193. Epub 2019 Apr 23. J Med Chem. 2019. PMID: 31013090 Free PMC article.
Synthesis and SAR of vinca alkaloid analogues.
Voss ME, Ralph JM, Xie D, Manning DD, Chen X, Frank AJ, Leyhane AJ, Liu L, Stevens JM, Budde C, Surman MD, Friedrich T, Peace D, Scott IL, Wolf M, Johnson R. Voss ME, et al. Among authors: surman md. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1245-9. doi: 10.1016/j.bmcl.2008.12.077. Epub 2008 Dec 25. Bioorg Med Chem Lett. 2009. PMID: 19147348
Tetrahydrocarboline analogs as MCH-1 antagonists.
Henderson AJ, Deering D, Grabowski JF, Hadden M, Jiang X, Khmelnitsky Y, Luche M, Surman MD, Cheetham S, Vickers S, Viggers J, Guzzo PR. Henderson AJ, et al. Among authors: surman md. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7024-8. doi: 10.1016/j.bmcl.2010.09.122. Epub 2010 Sep 29. Bioorg Med Chem Lett. 2010. PMID: 20952195
5-(pyridinon-1-yl)indazoles and 5-(furopyridinon-5-yl)indazoles as MCH-1 antagonists.
Surman MD, Freeman EE, Grabowski JF, Hadden M, Henderson AJ, Jiang G, Jiang XM, Luche M, Khmelnitsky Y, Vickers S, Viggers J, Cheetham S, Guzzo PR. Surman MD, et al. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7015-9. doi: 10.1016/j.bmcl.2010.09.039. Epub 2010 Sep 16. Bioorg Med Chem Lett. 2010. PMID: 20961756
Discovery of 2-amino-3-amido-5-aryl-pyridines as highly potent, orally bioavailable, and efficacious PERK kinase inhibitors.
Calvo V, Surguladze D, Li AH, Surman MD, Malibhatla S, Bandaru M, Jonnalagadda SK, Adarasandi R, Velmala M, Singireddi DRP, Velpuri M, Nareddy BR, Sastry V, Mandati C, Guguloth R, Siddiqui S, Patil BS, Chad E, Wolfley J, Gasparek J, Feldman K, Betzenhauser M, Wiens B, Koszelak-Rosenblum M, Zhu G, Du H, Rigby AC, Mulvihill MJ. Calvo V, et al. Among authors: surman md. Bioorg Med Chem Lett. 2021 Jul 1;43:128058. doi: 10.1016/j.bmcl.2021.128058. Epub 2021 Apr 23. Bioorg Med Chem Lett. 2021. PMID: 33895276 Free article.
Discovery of Selective Inhibitors for In Vitro and In Vivo Interrogation of Skeletal Myosin II.
Radnai L, Surman M, Hafenbreidel M, Young EJ, Stremel RF, Lin L, Bdiri B, Pasetto P, Jin X, Geedy M, Partridge JR, Patel A, Conlon M, Sellers JR, Cameron MD, Rumbaugh G, Griffin PR, Kamenecka TM, Miller CA. Radnai L, et al. Among authors: surman m. ACS Chem Biol. 2021 Nov 19;16(11):2164-2173. doi: 10.1021/acschembio.1c00067. Epub 2021 Sep 24. ACS Chem Biol. 2021. PMID: 34558887
15 results