Imai T - Search Results

1

Anti-Apoptotic Effects of Recombinant Human Hepatocyte Growth Factor on Hepatocytes Were Associated with Intrahepatic Hemorrhage Suppression Indicated by the Preservation of Prothrombin Time.

Motoi S, Toyoda H, Obara T, Ohta E, Arita Y, Negishi K, Moriya K, Kuboi Y, Soejima M, Imai T, Ido A, Tsubouchi H, Kawano T. Motoi S, et al. Among authors: imai t. Int J Mol Sci. 2019 Apr 12;20(8):1821. doi: 10.3390/ijms20081821. Int J Mol Sci. 2019. PMID: 31013780 Free PMC article.

2

Chemokines as novel therapeutic targets for inflammatory bowel disease.

Nishimura M, Kuboi Y, Muramoto K, Kawano T, Imai T. Nishimura M, et al. Among authors: imai t. Ann N Y Acad Sci. 2009 Sep;1173:350-6. doi: 10.1111/j.1749-6632.2009.04738.x. Ann N Y Acad Sci. 2009. PMID: 19758172 Review.

3

Inhibition of CCL20 increases mortality in models of mouse sepsis with intestinal apoptosis.

Kitagawa Y, Kikuchi S, Arita Y, Nishimura M, Mizuno K, Ogasawara H, Kawano T, Ochiai T, Otsuji E, Imai T. Kitagawa Y, et al. Among authors: imai t. Surgery. 2013 Jul;154(1):78-88. doi: 10.1016/j.surg.2013.02.012. Epub 2013 Apr 16. Surgery. 2013. PMID: 23601903

4

Safety, pharmacokinetics, and efficacy of E6011, an antifractalkine monoclonal antibody, in a first-in-patient phase 1/2 study on rheumatoid arthritis.

Tanaka Y, Takeuchi T, Umehara H, Nanki T, Yasuda N, Tago F, Kawakubo M, Kitahara Y, Hojo S, Kawano T, Imai T. Tanaka Y, et al. Among authors: imai t. Mod Rheumatol. 2018 Jan;28(1):58-65. doi: 10.1080/14397595.2017.1337056. Epub 2017 Jul 6. Mod Rheumatol. 2018. PMID: 28681650 Clinical Trial.

5

E6130, a Novel CX3C Chemokine Receptor 1 (CX3CR1) Modulator, Attenuates Mucosal Inflammation and Reduces CX3CR1⁺ Leukocyte Trafficking in Mice with Colitis.

Wakita H, Yanagawa T, Kuboi Y, Imai T. Wakita H, et al. Among authors: imai t. Mol Pharmacol. 2017 Nov;92(5):502-509. doi: 10.1124/mol.117.108381. Epub 2017 Aug 25. Mol Pharmacol. 2017. PMID: 28842393

6

Role of Anti-Fractalkine Antibody in Suppression of Joint Destruction by Inhibiting Migration of Osteoclast Precursors to the Synovium in Experimental Arthritis.

Hoshino-Negishi K, Ohkuro M, Nakatani T, Kuboi Y, Nishimura M, Ida Y, Kakuta J, Hamaguchi A, Kumai M, Kamisako T, Sugiyama F, Ikeda W, Ishii N, Yasuda N, Imai T. Hoshino-Negishi K, et al. Among authors: imai t. Arthritis Rheumatol. 2019 Feb;71(2):222-231. doi: 10.1002/art.40688. Arthritis Rheumatol. 2019. PMID: 30079992

7

Pharmacokinetics, Pharmacodynamics, and Safety of E6011, a Novel Humanized Antifractalkine (CX3CL1) Monoclonal Antibody: A Randomized, Double-Blind, Placebo-Controlled Single-Ascending-Dose Study.

Tabuchi H, Katsurabara T, Mori M, Aoyama M, Obara T, Yasuda N, Kawano T, Imai T, Ieiri I, Kumagai Y. Tabuchi H, et al. Among authors: imai t. J Clin Pharmacol. 2019 May;59(5):688-701. doi: 10.1002/jcph.1361. Epub 2018 Dec 21. J Clin Pharmacol. 2019. PMID: 30575978 Clinical Trial.

8

Blockade of the fractalkine-CX3CR1 axis ameliorates experimental colitis by dislodging venous crawling monocytes.

Kuboi Y, Nishimura M, Ikeda W, Nakatani T, Seki Y, Yamaura Y, Ogawa K, Hamaguchi A, Muramoto K, Mizuno K, Ogasawara H, Yamauchi T, Yasuda N, Onodera H, Imai T. Kuboi Y, et al. Among authors: imai t. Int Immunol. 2019 Apr 26;31(5):287-302. doi: 10.1093/intimm/dxz006. Int Immunol. 2019. PMID: 30668715

9

Blockade of the fractalkine-CX3CR1 axis ameliorates experimental colitis by dislodging venous crawling monocytes.

Kuboi Y, Nishimura M, Ikeda W, Nakatani T, Seki Y, Yamaura Y, Ogawa K, Hamaguchi A, Muramoto K, Mizuno K, Ogasawara H, Yamauchi T, Yasuda N, Onodera H, Imai T. Kuboi Y, et al. Among authors: imai t. Int Immunol. 2019 Apr 26;31(5):357. doi: 10.1093/intimm/dxz035. Int Immunol. 2019. PMID: 31002334 No abstract available.

10

Inhibition of the Progression of Skin Inflammation, Fibrosis, and Vascular Injury by Blockade of the CX₃ CL1/CX₃ CR1 Pathway in Experimental Mouse Models of Systemic Sclerosis.

Luong VH, Utsunomiya A, Chino T, Doanh LH, Matsushita T, Obara T, Kuboi Y, Ishii N, Machinaga A, Ogasawara H, Ikeda W, Kawano T, Imai T, Oyama N, Hasegawa M. Luong VH, et al. Among authors: imai t. Arthritis Rheumatol. 2019 Nov;71(11):1923-1934. doi: 10.1002/art.41009. Epub 2019 Sep 11. Arthritis Rheumatol. 2019. PMID: 31173491

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