Nishimaki-Mogami T - Search Results

1

Identification of potent farnesoid X receptor (FXR) antagonist showing favorable PK profile and distribution toward target tissues: Comprehensive understanding of structure-activity relationship of FXR antagonists.

Teno N, Yamashita Y, Masuda A, Iguchi Y, Oda K, Fujimori K, Hiramoto T, Nishimaki-Mogami T, Une M, Gohda K. Teno N, et al. Among authors: nishimaki mogami t. Bioorg Med Chem. 2019 Jun 1;27(11):2220-2227. doi: 10.1016/j.bmc.2019.04.029. Epub 2019 Apr 20. Bioorg Med Chem. 2019. PMID: 31029550

2

Structure-activity relationship of bile alcohols as human farnesoid X receptor agonist.

Iguchi Y, Kihira K, Nishimaki-Mogami T, Une M. Iguchi Y, et al. Steroids. 2010 Jan;75(1):95-100. doi: 10.1016/j.steroids.2009.11.002. Epub 2009 Nov 12. Steroids. 2010. PMID: 19913569

3

Discovery and optimization of benzimidazole derivatives as a novel chemotype of farnesoid X receptor (FXR) antagonists.

Teno N, Iguchi Y, Yamashita Y, Mori N, Une M, Nishimaki-Mogami T, Gohda K. Teno N, et al. Among authors: nishimaki mogami t. Bioorg Med Chem. 2017 Mar 15;25(6):1787-1794. doi: 10.1016/j.bmc.2017.01.040. Epub 2017 Jan 31. Bioorg Med Chem. 2017. PMID: 28190654

4

Nonacidic Chemotype Possessing N-Acylated Piperidine Moiety as Potent Farnesoid X Receptor (FXR) Antagonists.

Teno N, Yamashita Y, Iguchi Y, Fujimori K, Une M, Nishimaki-Mogami T, Hiramoto T, Gohda K. Teno N, et al. Among authors: nishimaki mogami t. ACS Med Chem Lett. 2018 Jan 4;9(2):78-83. doi: 10.1021/acsmedchemlett.7b00363. eCollection 2018 Feb 8. ACS Med Chem Lett. 2018. PMID: 29456791 Free PMC article.

5

Structure-activity relationship of bile acids and bile acid analogs in regard to FXR activation.

Fujino T, Une M, Imanaka T, Inoue K, Nishimaki-Mogami T. Fujino T, et al. J Lipid Res. 2004 Jan;45(1):132-8. doi: 10.1194/jlr.M300215-JLR200. Epub 2003 Sep 16. J Lipid Res. 2004. PMID: 13130122 Free article.

6

5Alpha-bile alcohols function as farnesoid X receptor antagonists.

Nishimaki-Mogami T, Kawahara Y, Tamehiro N, Yoshida T, Inoue K, Ohno Y, Nagao T, Une M. Nishimaki-Mogami T, et al. Biochem Biophys Res Commun. 2006 Jan 6;339(1):386-91. doi: 10.1016/j.bbrc.2005.11.027. Epub 2005 Nov 14. Biochem Biophys Res Commun. 2006. PMID: 16300737

7

Identification of intermediates in the bile acid synthetic pathway as ligands for the farnesoid X receptor.

Nishimaki-Mogami T, Une M, Fujino T, Sato Y, Tamehiro N, Kawahara Y, Shudo K, Inoue K. Nishimaki-Mogami T, et al. J Lipid Res. 2004 Aug;45(8):1538-45. doi: 10.1194/jlr.M400102-JLR200. Epub 2004 May 16. J Lipid Res. 2004. PMID: 15145977 Free article.

8

Bile alcohols function as the ligands of membrane-type bile acid-activated G protein-coupled receptor.

Iguchi Y, Yamaguchi M, Sato H, Kihira K, Nishimaki-Mogami T, Une M. Iguchi Y, et al. J Lipid Res. 2010 Jun;51(6):1432-41. doi: 10.1194/jlr.M004051. Epub 2009 Dec 18. J Lipid Res. 2010. PMID: 20023205 Free PMC article.

9

Effects of chemical modification of ursodeoxycholic acid on TGR5 activation.

Iguchi Y, Nishimaki-Mogami T, Yamaguchi M, Teraoka F, Kaneko T, Une M. Iguchi Y, et al. Biol Pharm Bull. 2011;34(1):1-7. doi: 10.1248/bpb.34.1. Biol Pharm Bull. 2011. PMID: 21212509 Free article.

10

In vitro farnesoid X receptor ligand sensor assay using surface plasmon resonance and based on ligand-induced coactivator association.

Fujino T, Sato Y, Une M, Kanayasu-Toyoda T, Yamaguchi T, Shudo K, Inoue K, Nishimaki-Mogami T. Fujino T, et al. J Steroid Biochem Mol Biol. 2003 Dec;87(4-5):247-52. doi: 10.1016/j.jsbmb.2003.09.008. J Steroid Biochem Mol Biol. 2003. PMID: 14698205

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