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Low Plasma IL-8 Levels During Chemotherapy Are Predictive of Excellent Long-Term Survival in Metastatic Breast Cancer.
Tiainen L, Hämäläinen M, Luukkaala T, Tanner M, Lahdenperä O, Vihinen P, Jukkola A, Karihtala P, Moilanen E, Kellokumpu-Lehtinen PL. Tiainen L, et al. Among authors: hamalainen m. Clin Breast Cancer. 2019 Aug;19(4):e522-e533. doi: 10.1016/j.clbc.2019.03.006. Epub 2019 Apr 4. Clin Breast Cancer. 2019. PMID: 31029558 Free article. Clinical Trial.
Orazipone inhibits activation of inflammatory transcription factors nuclear factor-kappa B and signal transducer and activator of transcription 1 and decreases inducible nitric-oxide synthase expression and nitric oxide production in response to inflammatory stimuli.
Sareila O, Hämäläinen M, Nissinen E, Kankaanranta H, Moilanen E. Sareila O, et al. Among authors: hamalainen m. J Pharmacol Exp Ther. 2008 Feb;324(2):858-66. doi: 10.1124/jpet.107.129114. Epub 2007 Nov 26. J Pharmacol Exp Ther. 2008. PMID: 18039960
Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages.
Hämäläinen M, Nieminen R, Vuorela P, Heinonen M, Moilanen E. Hämäläinen M, et al. Mediators Inflamm. 2007;2007:45673. doi: 10.1155/2007/45673. Mediators Inflamm. 2007. PMID: 18274639 Free PMC article.
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