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Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques.
Lee JH, Yang DS, Goulbourne CN, Im E, Stavrides P, Pensalfini A, Chan H, Bouchet-Marquis C, Bleiwas C, Berg MJ, Huo C, Peddy J, Pawlik M, Levy E, Rao M, Staufenbiel M, Nixon RA. Lee JH, et al. Among authors: im e. Nat Neurosci. 2022 Jun;25(6):688-701. doi: 10.1038/s41593-022-01084-8. Epub 2022 Jun 2. Nat Neurosci. 2022. PMID: 35654956 Free PMC article.
The three-dimensional landscape of cortical chromatin accessibility in Alzheimer's disease.
Bendl J, Hauberg ME, Girdhar K, Im E, Vicari JM, Rahman S, Fernando MB, Townsley KG, Dong P, Misir R, Kleopoulos SP, Reach SM, Apontes P, Zeng B, Zhang W, Voloudakis G, Brennand KJ, Nixon RA, Haroutunian V, Hoffman GE, Fullard JF, Roussos P. Bendl J, et al. Among authors: im e. Nat Neurosci. 2022 Oct;25(10):1366-1378. doi: 10.1038/s41593-022-01166-7. Epub 2022 Sep 28. Nat Neurosci. 2022. PMID: 36171428 Free PMC article.
Parkin directly modulates 26S proteasome activity.
Um JW, Im E, Lee HJ, Min B, Yoo L, Yoo J, Lübbert H, Stichel-Gunkel C, Cho HS, Yoon JB, Chung KC. Um JW, et al. Among authors: im e. J Neurosci. 2010 Sep 1;30(35):11805-14. doi: 10.1523/JNEUROSCI.2862-09.2010. J Neurosci. 2010. PMID: 20810900 Free PMC article.
ASK1 negatively regulates the 26 S proteasome.
Um JW, Im E, Park J, Oh Y, Min B, Lee HJ, Yoon JB, Chung KC. Um JW, et al. Among authors: im e. J Biol Chem. 2010 Nov 19;285(47):36434-46. doi: 10.1074/jbc.M110.133777. Epub 2010 Sep 15. J Biol Chem. 2010. PMID: 20843792 Free PMC article.
550 results