Derks M - Search Results

1

A phase 2 clinical trial of a vasopressin V1a receptor antagonist shows improved adaptive behaviors in men with autism spectrum disorder.

Bolognani F, Del Valle Rubido M, Squassante L, Wandel C, Derks M, Murtagh L, Sevigny J, Khwaja O, Umbricht D, Fontoura P. Bolognani F, et al. Among authors: derks m. Sci Transl Med. 2019 May 8;11(491):eaat7838. doi: 10.1126/scitranslmed.aat7838. Epub 2019 May 1. Sci Transl Med. 2019. PMID: 31043521 Clinical Trial.

2

Population Pharmacokinetic and Exposure-dizziness Modeling for a Metabotropic Glutamate Receptor Subtype 5 Negative Allosteric Modulator in Major Depressive Disorder Patients.

Cosson V, Schaedeli-Stark F, Arab-Alameddine M, Chavanne C, Guerini E, Derks M, Mallalieu NL. Cosson V, et al. Among authors: derks m. Clin Transl Sci. 2018 Sep;11(5):523-531. doi: 10.1111/cts.12566. Epub 2018 Jun 27. Clin Transl Sci. 2018. PMID: 29877614 Free PMC article. Clinical Trial.

3

PKPD and cardiac single cell modeling of a DDI study with a CYP3A4 substrate and itraconazole to quantify the effects on QT interval duration.

Jaminion F, Bentley D, Wang K, Wandel C, Derks M, Diack C. Jaminion F, et al. Among authors: derks m. J Pharmacokinet Pharmacodyn. 2020 Oct;47(5):447-459. doi: 10.1007/s10928-020-09696-y. Epub 2020 Jun 22. J Pharmacokinet Pharmacodyn. 2020. PMID: 32572738 Clinical Trial.

4

Open-Label Assessment of the Effects of Itraconazole and Rifampicin on Balovaptan Pharmacokinetics in Healthy Volunteers.

Derks MGM, Wandel C, Young A, Bolt SK, Meyenberg C. Derks MGM, et al. Adv Ther. 2020 Nov;37(11):4720-4729. doi: 10.1007/s12325-020-01491-y. Epub 2020 Sep 15. Adv Ther. 2020. PMID: 32935287

5

Basmisanil, a highly selective GABA_A-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man.

Hipp JF, Knoflach F, Comley R, Ballard TM, Honer M, Trube G, Gasser R, Prinssen E, Wallace TL, Rothfuss A, Knust H, Lennon-Chrimes S, Derks M, Bentley D, Squassante L, Nave S, Nöldeke J, Wandel C, Thomas AW, Hernandez MC. Hipp JF, et al. Among authors: derks m. Sci Rep. 2021 Apr 8;11(1):7700. doi: 10.1038/s41598-021-87307-7. Sci Rep. 2021. PMID: 33833333 Free PMC article.

6

Bioavailability and pharmacokinetic profile of balovaptan, a selective, brain-penetrant vasopressin 1a receptor antagonist, in healthy volunteers.

Derks M, Lennon-Chrimes S, Guenther A, Squassante L, Wandel C, Szczesny P, Paehler A, Kletzl H. Derks M, et al. Expert Opin Investig Drugs. 2021 Aug;30(8):893-901. doi: 10.1080/13543784.2021.1948009. Epub 2021 Jul 16. Expert Opin Investig Drugs. 2021. PMID: 34176392 Clinical Trial.

7

A randomized, double-blind, placebo-controlled phase II trial to explore the effects of a GABA_A-α5 NAM (basmisanil) on intellectual disability associated with Down syndrome.

Goeldner C, Kishnani PS, Skotko BG, Casero JL, Hipp JF, Derks M, Hernandez MC, Khwaja O, Lennon-Chrimes S, Noeldeke J, Pellicer S, Squassante L, Visootsak J, Wandel C, Fontoura P, d'Ardhuy XL; Clematis Study Group. Goeldner C, et al. Among authors: derks m. J Neurodev Disord. 2022 Feb 5;14(1):10. doi: 10.1186/s11689-022-09418-0. J Neurodev Disord. 2022. PMID: 35123401 Free PMC article. Clinical Trial.

8

Safety, tolerability and pharmacokinetics of dalcetrapib following single and multiple ascending doses in healthy subjects: a randomized, double-blind, placebo-controlled, phase I study.

Derks M, Anzures-Cabrera J, Turnbull L, Phelan M. Derks M, et al. Clin Drug Investig. 2011;31(5):325-35. doi: 10.1007/BF03256931. Clin Drug Investig. 2011. PMID: 21366361 Clinical Trial.

9

Results and evaluation of a first-in-human study of RG7342, an mGlu5 positive allosteric modulator, utilizing Bayesian adaptive methods.

Sturm S, Delporte ML, Hadi S, Schobel S, Lindemann L, Weikert R, Jaeschke G, Derks M, Palermo G. Sturm S, et al. Among authors: derks m. Br J Clin Pharmacol. 2018 Mar;84(3):445-455. doi: 10.1111/bcp.13466. Epub 2017 Dec 18. Br J Clin Pharmacol. 2018. PMID: 29096426 Free PMC article. Clinical Trial.

10

Efficacy and safety of balovaptan for posttraumatic stress disorder: A randomized, placebo-controlled trial.

Marler S, Rabbia M, Sanders K, Derks M, Bailey L, Vilimovskij A, Maurer J, Nordstroem AL, Guthrie H. Marler S, et al. Among authors: derks m. Exp Clin Psychopharmacol. 2025 Feb;33(1):43-52. doi: 10.1037/pha0000740. Epub 2024 Nov 11. Exp Clin Psychopharmacol. 2025. PMID: 39531689 Clinical Trial.

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