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Benzoxazinone-containing 3,5-dimethylisoxazole derivatives as BET bromodomain inhibitors for treatment of castration-resistant prostate cancer.
Xue X, Zhang Y, Wang C, Zhang M, Xiang Q, Wang J, Wang A, Li C, Zhang C, Zou L, Wang R, Wu S, Lu Y, Chen H, Ding K, Li G, Xu Y. Xue X, et al. Among authors: zhang m, zhang c, zhang y. Eur J Med Chem. 2018 May 25;152:542-559. doi: 10.1016/j.ejmech.2018.04.034. Epub 2018 Apr 21. Eur J Med Chem. 2018. PMID: 29758518
Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable RORγ Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer.
Zhang Y, Wu X, Xue X, Li C, Wang J, Wang R, Zhang C, Wang C, Shi Y, Zou L, Li Q, Huang Z, Hao X, Loomes K, Wu D, Chen HW, Xu J, Xu Y. Zhang Y, et al. Among authors: zhang c. J Med Chem. 2019 May 9;62(9):4716-4730. doi: 10.1021/acs.jmedchem.9b00327. Epub 2019 Apr 22. J Med Chem. 2019. PMID: 30964293
Discovery and optimization of novel N-benzyl-3,6-dimethylbenzo[d]isoxazol-5-amine derivatives as potent and selective TRIM24 bromodomain inhibitors with potential anti-cancer activities.
Hu Q, Wang C, Xiang Q, Wang R, Zhang C, Zhang M, Xue X, Luo G, Liu X, Wu X, Zhang Y, Wu D, Xu Y. Hu Q, et al. Among authors: zhang m, zhang c, zhang y. Bioorg Chem. 2020 Jan;94:103424. doi: 10.1016/j.bioorg.2019.103424. Epub 2019 Nov 9. Bioorg Chem. 2020. PMID: 31776034
Y06014 is a selective BET inhibitor for the treatment of prostate cancer.
Wu TB, Xiang QP, Wang C, Wu C, Zhang C, Zhang MF, Liu ZX, Zhang Y, Xiao LJ, Xu Y. Wu TB, et al. Among authors: zhang c, zhang mf, zhang y. Acta Pharmacol Sin. 2021 Dec;42(12):2120-2131. doi: 10.1038/s41401-021-00614-7. Epub 2021 Mar 2. Acta Pharmacol Sin. 2021. PMID: 33654218 Free PMC article.
Structure-Based Discovery and Optimization of Furo[3,2-c]pyridin-4(5H)-one Derivatives as Potent and Second Bromodomain (BD2)-Selective Bromo and Extra Terminal Domain (BET) Inhibitors.
Li J, Zhang C, Xu H, Wang C, Dong R, Shen H, Zhuang X, Chen X, Li Q, Lu J, Zhang M, Wu X, Loomes KM, Zhou Y, Zhang Y, Liu J, Xu Y. Li J, et al. Among authors: zhang m, zhang c, zhang y. J Med Chem. 2022 Apr 14;65(7):5760-5799. doi: 10.1021/acs.jmedchem.2c00100. Epub 2022 Mar 25. J Med Chem. 2022. PMID: 35333526
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