Ruan B - Search Results

1

Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR.

Zhang X, Chen W, Gao Q, Yang J, Yan X, Zhao H, Su L, Yang M, Gao C, Yao Y, Inoki K, Li D, Shao R, Wang S, Sahoo N, Kudo F, Eguchi T, Ruan B, Xu H. Zhang X, et al. Among authors: ruan b. PLoS Biol. 2019 May 21;17(5):e3000252. doi: 10.1371/journal.pbio.3000252. eCollection 2019 May. PLoS Biol. 2019. PMID: 31112550 Free PMC article.

2

Click chemistry-based synthesis and anticancer activity evaluation of novel C-14 1,2,3-triazole dehydroabietic acid hybrids.

Hou W, Luo Z, Zhang G, Cao D, Li D, Ruan H, Ruan BH, Su L, Xu H. Hou W, et al. Eur J Med Chem. 2017 Sep 29;138:1042-1052. doi: 10.1016/j.ejmech.2017.07.049. Epub 2017 Jul 24. Eur J Med Chem. 2017. PMID: 28759877

3

Ebselen: Mechanisms of Glutamate Dehydrogenase and Glutaminase Enzyme Inhibition.

Yu Y, Jin Y, Zhou J, Ruan H, Zhao H, Lu S, Zhang Y, Li D, Ji X, Ruan BH. Yu Y, et al. ACS Chem Biol. 2017 Dec 15;12(12):3003-3011. doi: 10.1021/acschembio.7b00728. Epub 2017 Nov 7. ACS Chem Biol. 2017. PMID: 29072450

4

Identification of a diverse synthetic abietane diterpenoid library and insight into the structure-activity relationships for antibacterial activity.

Hou W, Zhang G, Luo Z, Li D, Ruan H, Ruan BH, Su L, Xu H. Hou W, et al. Bioorg Med Chem Lett. 2017 Dec 15;27(24):5382-5386. doi: 10.1016/j.bmcl.2017.11.014. Epub 2017 Nov 9. Bioorg Med Chem Lett. 2017. PMID: 29153424

5

Ebselen Reversibly Inhibits Human Glutamate Dehydrogenase at the Catalytic Site.

Jin Y, Li D, Lu S, Zhao H, Chen Z, Hou W, Ruan BH. Jin Y, et al. Assay Drug Dev Technol. 2018 Feb/Mar;16(2):115-122. doi: 10.1089/adt.2017.822. Epub 2018 Feb 22. Assay Drug Dev Technol. 2018. PMID: 29470101

6

FITC-labeled d-glucose analog is suitable as a probe for detecting insulin-dependent glucose uptake.

Su L, Wu R, Chen X, Hou W, Ruan BH. Su L, et al. Bioorg Med Chem Lett. 2018 Dec 1;28(22):3560-3563. doi: 10.1016/j.bmcl.2018.09.027. Epub 2018 Sep 21. Bioorg Med Chem Lett. 2018. PMID: 30293953

7

Propylselen inhibits cancer cell growth by targeting glutamate dehydrogenase at the NADP⁺ binding site.

Hou W, Lu S, Zhao H, Yu Y, Xu H, Yu B, Su L, Lin C, Ruan BH. Hou W, et al. Among authors: ruan bh. Biochem Biophys Res Commun. 2019 Jan 29;509(1):262-267. doi: 10.1016/j.bbrc.2018.12.117. Epub 2018 Dec 22. Biochem Biophys Res Commun. 2019. PMID: 30583861

8

Design and synthesis of biotinylated Hexylselen as a probe to identify KGA allosteric inhibitors by a convenient biomolecular interaction assay.

Hou W, Fang J, Su L, Ye H, Ruan BH. Hou W, et al. Bioorg Med Chem Lett. 2019 Sep 1;29(17):2498-2502. doi: 10.1016/j.bmcl.2019.07.014. Epub 2019 Jul 9. Bioorg Med Chem Lett. 2019. PMID: 31324513

9

The EZMTT cell proliferation assay provides precise measurement for drug combinations and better correlation between in vitro and in vivo efficacy.

Rui J, Xu N, Yin J, Yu Y, Bai R, Su W, Ruan B. Rui J, et al. Among authors: ruan b. Bioorg Med Chem Lett. 2020 Jun 1;30(11):127134. doi: 10.1016/j.bmcl.2020.127134. Epub 2020 Mar 20. Bioorg Med Chem Lett. 2020. PMID: 32253062

10

Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities.

Ruan B, Pong K, Jow F, Bowlby M, Crozier RA, Liu D, Liang S, Chen Y, Mercado ML, Feng X, Bennett F, von Schack D, McDonald L, Zaleska MM, Wood A, Reinhart PH, Magolda RL, Skotnicki J, Pangalos MN, Koehn FE, Carter GT, Abou-Gharbia M, Graziani EI. Ruan B, et al. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):33-8. doi: 10.1073/pnas.0710424105. Epub 2007 Dec 27. Proc Natl Acad Sci U S A. 2008. PMID: 18162540 Free PMC article.

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