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Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR.
Zhang X, Chen W, Gao Q, Yang J, Yan X, Zhao H, Su L, Yang M, Gao C, Yao Y, Inoki K, Li D, Shao R, Wang S, Sahoo N, Kudo F, Eguchi T, Ruan B, Xu H. Zhang X, et al. Among authors: yang m, yang j. PLoS Biol. 2019 May 21;17(5):e3000252. doi: 10.1371/journal.pbio.3000252. eCollection 2019 May. PLoS Biol. 2019. PMID: 31112550 Free PMC article.
MCOLN1 is a ROS sensor in lysosomes that regulates autophagy.
Zhang X, Cheng X, Yu L, Yang J, Calvo R, Patnaik S, Hu X, Gao Q, Yang M, Lawas M, Delling M, Marugan J, Ferrer M, Xu H. Zhang X, et al. Among authors: yang m, yang j. Nat Commun. 2016 Jun 30;7:12109. doi: 10.1038/ncomms12109. Nat Commun. 2016. PMID: 27357649 Free PMC article.
Gastric Acid Secretion from Parietal Cells Is Mediated by a Ca2+ Efflux Channel in the Tubulovesicle.
Sahoo N, Gu M, Zhang X, Raval N, Yang J, Bekier M, Calvo R, Patnaik S, Wang W, King G, Samie M, Gao Q, Sahoo S, Sundaresan S, Keeley TM, Wang Y, Marugan J, Ferrer M, Samuelson LC, Merchant JL, Xu H. Sahoo N, et al. Among authors: yang j. Dev Cell. 2017 May 8;41(3):262-273.e6. doi: 10.1016/j.devcel.2017.04.003. Dev Cell. 2017. PMID: 28486130 Free PMC article.
Release and uptake mechanisms of vesicular Ca2+ stores.
Yang J, Zhao Z, Gu M, Feng X, Xu H. Yang J, et al. Protein Cell. 2019 Jan;10(1):8-19. doi: 10.1007/s13238-018-0523-x. Epub 2018 Mar 16. Protein Cell. 2019. PMID: 29549599 Free PMC article. Review.
Lysosomal Calcium in Neurodegeneration.
Feng X, Yang J. Feng X, et al. Among authors: yang j. Messenger (Los Angel). 2016 Jun;5(1-2):56-66. doi: 10.1166/msr.2016.1055. Epub 2016 Jun 1. Messenger (Los Angel). 2016. PMID: 29082116 Free PMC article.
Ion channels as potential redox sensors in lysosomes.
Yu J, Yang J. Yu J, et al. Among authors: yang j. Channels (Austin). 2019 Dec;13(1):477-482. doi: 10.1080/19336950.2019.1684428. Channels (Austin). 2019. PMID: 31662029 Free PMC article. Review.
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