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Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR.
Zhang X, Chen W, Gao Q, Yang J, Yan X, Zhao H, Su L, Yang M, Gao C, Yao Y, Inoki K, Li D, Shao R, Wang S, Sahoo N, Kudo F, Eguchi T, Ruan B, Xu H. Zhang X, et al. PLoS Biol. 2019 May 21;17(5):e3000252. doi: 10.1371/journal.pbio.3000252. eCollection 2019 May. PLoS Biol. 2019. PMID: 31112550 Free PMC article.
Organellar TRP channels.
Zhang X, Hu M, Yang Y, Xu H. Zhang X, et al. Nat Struct Mol Biol. 2018 Nov;25(11):1009-1018. doi: 10.1038/s41594-018-0148-z. Epub 2018 Oct 29. Nat Struct Mol Biol. 2018. PMID: 30374082 Free PMC article. Review.
TRPML1: an ion channel in the lysosome.
Wang W, Zhang X, Gao Q, Xu H. Wang W, et al. Among authors: zhang x. Handb Exp Pharmacol. 2014;222:631-45. doi: 10.1007/978-3-642-54215-2_24. Handb Exp Pharmacol. 2014. PMID: 24756723 Review.
MCOLN1 is a ROS sensor in lysosomes that regulates autophagy.
Zhang X, Cheng X, Yu L, Yang J, Calvo R, Patnaik S, Hu X, Gao Q, Yang M, Lawas M, Delling M, Marugan J, Ferrer M, Xu H. Zhang X, et al. Nat Commun. 2016 Jun 30;7:12109. doi: 10.1038/ncomms12109. Nat Commun. 2016. PMID: 27357649 Free PMC article.
Lysosome calcium in ROS regulation of autophagy.
Zhang X, Yu L, Xu H. Zhang X, et al. Autophagy. 2016 Oct 2;12(10):1954-1955. doi: 10.1080/15548627.2016.1212787. Epub 2016 Aug 2. Autophagy. 2016. PMID: 27485905 Free PMC article.
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