Gijsen HJM - Search Results

1

Design and synthesis of a novel series of cyanoindole derivatives as potent γ-secretase modulators.

Bischoff FP, Velter AI, Minne G, Pieters S, Berthelot D, De Cleyn M, Gijsen HJM, Macdonald G, Surkyn M, Van Brandt S, Van Roosbroeck Y, Zavattaro C, Mercken M, Austin N, Dhuyvetter D, Borghys H, Ahmad I, Samanta SK. Bischoff FP, et al. Among authors: gijsen hjm. Bioorg Med Chem Lett. 2019 Jul 15;29(14):1737-1745. doi: 10.1016/j.bmcl.2019.05.023. Epub 2019 May 15. Bioorg Med Chem Lett. 2019. PMID: 31122869

2

5-Sulfonyl-benzimidazoles as selective CB2 agonists.

Verbist BM, De Cleyn MA, Surkyn M, Fraiponts E, Aerssens J, Nijsen MJ, Gijsen HJ. Verbist BM, et al. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2574-9. doi: 10.1016/j.bmcl.2008.03.048. Epub 2008 Mar 20. Bioorg Med Chem Lett. 2008. PMID: 18394887

3

Tear gasses CN, CR, and CS are potent activators of the human TRPA1 receptor.

Brône B, Peeters PJ, Marrannes R, Mercken M, Nuydens R, Meert T, Gijsen HJ. Brône B, et al. Toxicol Appl Pharmacol. 2008 Sep 1;231(2):150-6. doi: 10.1016/j.taap.2008.04.005. Epub 2008 Apr 20. Toxicol Appl Pharmacol. 2008. PMID: 18501939

4

Analogues of morphanthridine and the tear gas dibenz[b,f][1,4]oxazepine (CR) as extremely potent activators of the human transient receptor potential ankyrin 1 (TRPA1) channel.

Gijsen HJ, Berthelot D, Zaja M, Brône B, Geuens I, Mercken M. Gijsen HJ, et al. J Med Chem. 2010 Oct 14;53(19):7011-20. doi: 10.1021/jm100477n. J Med Chem. 2010. PMID: 20806939

5

γ-Secretase modulators as potential disease modifying anti-Alzheimer's drugs.

Oehlrich D, Berthelot DJ, Gijsen HJ. Oehlrich D, et al. J Med Chem. 2011 Feb 10;54(3):669-98. doi: 10.1021/jm101168r. Epub 2010 Dec 9. J Med Chem. 2011. PMID: 21141968 Review. No abstract available.

6

Rational design and synthesis of aminopiperazinones as β-secretase (BACE) inhibitors.

Tresadern G, Delgado F, Delgado O, Gijsen H, Macdonald GJ, Moechars D, Rombouts F, Alexander R, Spurlino J, Van Gool M, Vega JA, Trabanco AA. Tresadern G, et al. Bioorg Med Chem Lett. 2011 Dec 15;21(24):7255-60. doi: 10.1016/j.bmcl.2011.10.050. Epub 2011 Oct 20. Bioorg Med Chem Lett. 2011. PMID: 22071305

7

A canine model to evaluate efficacy and safety of γ-secretase inhibitors and modulators.

Borghys H, Tuefferd M, Van Broeck B, Clessens E, Dillen L, Cools W, Vinken P, Straetemans R, De Ridder F, Gijsen H, Mercken M. Borghys H, et al. J Alzheimers Dis. 2012;28(4):809-22. doi: 10.3233/JAD-2011-111475. J Alzheimers Dis. 2012. PMID: 22072214

8

5-sulfonyl-benzimidazoles as selective CB2 agonists-part 2.

Gijsen HJ, De Cleyn MA, Surkyn M, Van Lommen GR, Verbist BM, Nijsen MJ, Meert T, Wauwe JV, Aerssens J. Gijsen HJ, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):547-52. doi: 10.1016/j.bmcl.2011.10.091. Epub 2011 Nov 6. Bioorg Med Chem Lett. 2012. PMID: 22130134

9

Tricyclic 3,4-dihydropyrimidine-2-thione derivatives as potent TRPA1 antagonists.

Gijsen HJ, Berthelot D, De Cleyn MA, Geuens I, Brône B, Mercken M. Gijsen HJ, et al. Bioorg Med Chem Lett. 2012 Jan 15;22(2):797-800. doi: 10.1016/j.bmcl.2011.12.068. Epub 2011 Dec 22. Bioorg Med Chem Lett. 2012. PMID: 22222037

10

Design and synthesis of a novel series of bicyclic heterocycles as potent γ-secretase modulators.

Bischoff F, Berthelot D, De Cleyn M, Macdonald G, Minne G, Oehlrich D, Pieters S, Surkyn M, Trabanco AA, Tresadern G, Van Brandt S, Velter I, Zaja M, Borghys H, Masungi C, Mercken M, Gijsen HJ. Bischoff F, et al. J Med Chem. 2012 Nov 8;55(21):9089-106. doi: 10.1021/jm201710f. Epub 2012 Jun 8. J Med Chem. 2012. PMID: 22650177

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