Chen XQ - Search Results

1

Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses.

Chen XQ, Mobley WC. Chen XQ, et al. Front Neurosci. 2019 May 7;13:446. doi: 10.3389/fnins.2019.00446. eCollection 2019. Front Neurosci. 2019. PMID: 31133787 Free PMC article. Review.

2

TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease.

Zhao X, Chen XQ, Han E, Hu Y, Paik P, Ding Z, Overman J, Lau AL, Shahmoradian SH, Chiu W, Thompson LM, Wu C, Mobley WC. Zhao X, et al. Among authors: chen xq. Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5655-64. doi: 10.1073/pnas.1603020113. Epub 2016 Sep 6. Proc Natl Acad Sci U S A. 2016. PMID: 27601642 Free PMC article.

3

Dysregulation of neurotrophin signaling in the pathogenesis of Alzheimer disease and of Alzheimer disease in Down syndrome.

Chen XQ, Sawa M, Mobley WC. Chen XQ, et al. Free Radic Biol Med. 2018 Jan;114:52-61. doi: 10.1016/j.freeradbiomed.2017.10.341. Epub 2017 Oct 12. Free Radic Biol Med. 2018. PMID: 29031834 Free PMC article. Review.

4

T-complex protein 1-ring complex enhances retrograde axonal transport by modulating tau phosphorylation.

Chen XQ, Fang F, Florio JB, Rockenstein E, Masliah E, Mobley WC, Rissman RA, Wu C. Chen XQ, et al. Traffic. 2018 Nov;19(11):840-853. doi: 10.1111/tra.12610. Epub 2018 Sep 12. Traffic. 2018. PMID: 30120810 Free PMC article.

5

Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species.

Chen XQ, Mobley WC. Chen XQ, et al. Front Neurosci. 2019 Jun 21;13:659. doi: 10.3389/fnins.2019.00659. eCollection 2019. Front Neurosci. 2019. PMID: 31293377 Free PMC article. Review.

6

Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model.

Chen XQ, Salehi A, Pearn ML, Overk C, Nguyen PD, Kleschevnikov AM, Maccecchini M, Mobley WC. Chen XQ, et al. Alzheimers Dement. 2021 Feb;17(2):271-292. doi: 10.1002/alz.12185. Epub 2020 Sep 25. Alzheimers Dement. 2021. PMID: 32975365 Free PMC article.

7

Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport.

Chen XQ, Das U, Park G, Mobley WC. Chen XQ, et al. Alzheimers Res Ther. 2021 Mar 10;13(1):59. doi: 10.1186/s13195-021-00796-6. Alzheimers Res Ther. 2021. PMID: 33691783 Free PMC article.

8

Mechanistic Analysis of Age-Related Clinical Manifestations in Down Syndrome.

Chen XQ, Xing Z, Chen QD, Salvi RJ, Zhang X, Tycko B, Mobley WC, Yu YE. Chen XQ, et al. Among authors: chen qd. Front Aging Neurosci. 2021 Jul 1;13:700280. doi: 10.3389/fnagi.2021.700280. eCollection 2021. Front Aging Neurosci. 2021. PMID: 34276349 Free PMC article.

9

Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose.

Chen XQ, Zuo X, Becker A, Head E, Mobley WC. Chen XQ, et al. Alzheimers Dement. 2023 May;19(5):2095-2116. doi: 10.1002/alz.12835. Epub 2022 Nov 12. Alzheimers Dement. 2023. PMID: 36370135 Free PMC article.

10

Retromer Proteins Reduced in Down Syndrome and the Dp16 Model: Impact of APP Dose and Preclinical Studies of a γ-Secretase Modulator.

Chen XQ, Sawa M, Becker A, Karachentsev D, Zuo X, Rynearson KD, Tanzi RE, Mobley WC. Chen XQ, et al. Ann Neurol. 2023 Aug;94(2):245-258. doi: 10.1002/ana.26659. Epub 2023 Apr 29. Ann Neurol. 2023. PMID: 37042072

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