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Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma.
Bandopadhayay P, Piccioni F, O'Rourke R, Ho P, Gonzalez EM, Buchan G, Qian K, Gionet G, Girard E, Coxon M, Rees MG, Brenan L, Dubois F, Shapira O, Greenwald NF, Pages M, Balboni Iniguez A, Paolella BR, Meng A, Sinai C, Roti G, Dharia NV, Creech A, Tanenbaum B, Khadka P, Tracy A, Tiv HL, Hong AL, Coy S, Rashid R, Lin JR, Cowley GS, Lam FC, Goodale A, Lee Y, Schoolcraft K, Vazquez F, Hahn WC, Tsherniak A, Bradner JE, Yaffe MB, Milde T, Pfister SM, Qi J, Schenone M, Carr SA, Ligon KL, Kieran MW, Santagata S, Olson JM, Gokhale PC, Jaffe JD, Root DE, Stegmaier K, Johannessen CM, Beroukhim R. Bandopadhayay P, et al. Among authors: buchan g. Nat Commun. 2019 Jun 3;10(1):2400. doi: 10.1038/s41467-019-10307-9. Nat Commun. 2019. PMID: 31160565 Free PMC article.
PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation.
Khadka P, Reitman ZJ, Lu S, Buchan G, Gionet G, Dubois F, Carvalho DM, Shih J, Zhang S, Greenwald NF, Zack T, Shapira O, Pelton K, Hartley R, Bear H, Georgis Y, Jarmale S, Melanson R, Bonanno K, Schoolcraft K, Miller PG, Condurat AL, Gonzalez EM, Qian K, Morin E, Langhnoja J, Lupien LE, Rendo V, Digiacomo J, Wang D, Zhou K, Kumbhani R, Guerra Garcia ME, Sinai CE, Becker S, Schneider R, Vogelzang J, Krug K, Goodale A, Abid T, Kalani Z, Piccioni F, Beroukhim R, Persky NS, Root DE, Carcaboso AM, Ebert BL, Fuller C, Babur O, Kieran MW, Jones C, Keshishian H, Ligon KL, Carr SA, Phoenix TN, Bandopadhayay P. Khadka P, et al. Among authors: buchan g. Nat Commun. 2022 Feb 1;13(1):604. doi: 10.1038/s41467-022-28198-8. Nat Commun. 2022. PMID: 35105861 Free PMC article.
Use of a fluoroscopy-based robotic-assisted total hip arthroplasty system produced greater improvements in patient-reported outcomes at one year compared to manual, fluoroscopic-assisted technique.
Buchan GBJ, Ong CB, Hecht Ii CJ, DeCook CA, Spencer-Gardner LS, Kamath AF. Buchan GBJ, et al. Arch Orthop Trauma Surg. 2024 Apr;144(4):1843-1850. doi: 10.1007/s00402-024-05230-8. Epub 2024 Feb 24. Arch Orthop Trauma Surg. 2024. PMID: 38400899 Free PMC article. Review.
Lipoxin A4 yields an electrophilic 15-oxo metabolite that mediates FPR2 receptor-independent anti-inflammatory signaling.
Koudelka A, Buchan GJ, Cechova V, O'Brien JP, Liu H, Woodcock SR, Mullett SJ, Zhang C, Freeman BA, Gelhaus SL. Koudelka A, et al. Among authors: buchan gj. bioRxiv [Preprint]. 2024 Feb 7:2024.02.06.579101. doi: 10.1101/2024.02.06.579101. bioRxiv. 2024. Update in: J Lipid Res. 2024 Nov 19;66(1):100705. doi: 10.1016/j.jlr.2024.100705 PMID: 38370667 Free PMC article. Updated. Preprint.
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