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Aerosol-, but not intradermal-immunization with the live vaccine strain of Francisella tularensis protects mice against subsequent aerosol challenge with a highly virulent type A strain of the pathogen by an alphabeta T cell- and interferon gamma- dependent mechanism.
Wayne Conlan J, Shen H, Kuolee R, Zhao X, Chen W. Wayne Conlan J, et al. Among authors: chen w. Vaccine. 2005 Mar 31;23(19):2477-85. doi: 10.1016/j.vaccine.2004.10.034. Vaccine. 2005. PMID: 15752834
Differential ability of novel attenuated targeted deletion mutants of Francisella tularensis subspecies tularensis strain SCHU S4 to protect mice against aerosol challenge with virulent bacteria: effects of host background and route of immunization.
Conlan JW, Shen H, Golovliov I, Zingmark C, Oyston PC, Chen W, House RV, Sjöstedt A. Conlan JW, et al. Among authors: chen w. Vaccine. 2010 Feb 17;28(7):1824-31. doi: 10.1016/j.vaccine.2009.12.001. Epub 2009 Dec 16. Vaccine. 2010. PMID: 20018266 Free PMC article.
BALB/c mice, but not C57BL/6 mice immunized with a ΔclpB mutant of Francisella tularensis subspecies tularensis are protected against respiratory challenge with wild-type bacteria: association of protection with post-vaccination and post-challenge immune responses.
Twine S, Shen H, Harris G, Chen W, Sjostedt A, Ryden P, Conlan W. Twine S, et al. Among authors: chen w. Vaccine. 2012 May 21;30(24):3634-45. doi: 10.1016/j.vaccine.2012.03.036. Epub 2012 Apr 3. Vaccine. 2012. PMID: 22484348
Design and immunological properties of Helicobacter pylori glycoconjugates based on a truncated lipopolysaccharide lacking Lewis antigen and comprising an α-1,6-glucan chain.
Altman E, Chandan V, Harrison BA, Veloso-Pita R, Li J, KuoLee R, Chen W, Vérez-Bencomo V; Regional Helicobacter pylori Study Group. Altman E, et al. Among authors: chen w. Vaccine. 2012 Nov 26;30(50):7332-41. doi: 10.1016/j.vaccine.2012.04.035. Epub 2012 Apr 22. Vaccine. 2012. PMID: 22534169
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