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A small-molecule inhibitor of C5 complement protein.
Jendza K, Kato M, Salcius M, Srinivas H, De Erkenez A, Nguyen A, McLaughlin D, Be C, Wiesmann C, Murphy J, Bolduc P, Mogi M, Duca J, Namil A, Capparelli M, Darsigny V, Meredith E, Tichkule R, Ferrara L, Heyder J, Liu F, Horton PA, Romanowski MJ, Schirle M, Mainolfi N, Anderson K, Michaud GA. Jendza K, et al. Among authors: murphy j. Nat Chem Biol. 2019 Jul;15(7):666-668. doi: 10.1038/s41589-019-0303-9. Epub 2019 Jun 17. Nat Chem Biol. 2019. PMID: 31209353
Natural products reveal cancer cell dependence on oxysterol-binding proteins.
Burgett AW, Poulsen TB, Wangkanont K, Anderson DR, Kikuchi C, Shimada K, Okubo S, Fortner KC, Mimaki Y, Kuroda M, Murphy JP, Schwalb DJ, Petrella EC, Cornella-Taracido I, Schirle M, Tallarico JA, Shair MD. Burgett AW, et al. Among authors: murphy jp. Nat Chem Biol. 2011 Aug 7;7(9):639-47. doi: 10.1038/nchembio.625. Nat Chem Biol. 2011. PMID: 21822274 Free PMC article.
Gift from Nature: Cyclomarin A Kills Mycobacteria and Malaria Parasites by Distinct Modes of Action.
Bürstner N, Roggo S, Ostermann N, Blank J, Delmas C, Freuler F, Gerhartz B, Hinniger A, Hoepfner D, Liechty B, Mihalic M, Murphy J, Pistorius D, Rottmann M, Thomas JR, Schirle M, Schmitt EK. Bürstner N, et al. Among authors: murphy j. Chembiochem. 2015 Nov;16(17):2433-6. doi: 10.1002/cbic.201500472. Epub 2015 Oct 16. Chembiochem. 2015. PMID: 26472355
CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma.
Ross NT, Lohmann F, Carbonneau S, Fazal A, Weihofen WA, Gleim S, Salcius M, Sigoillot F, Henault M, Carl SH, Rodríguez-Molina JB, Miller HR, Brittain SM, Murphy J, Zambrowski M, Boynton G, Wang Y, Chen A, Molind GJ, Wilbertz JH, Artus-Revel CG, Jia M, Akinjiyan FA, Turner J, Knehr J, Carbone W, Schuierer S, Reece-Hoyes JS, Xie K, Saran C, Williams ET, Roma G, Spencer M, Jenkins J, George EL, Thomas JR, Michaud G, Schirle M, Tallarico J, Passmore LA, Chao JA, Beckwith REJ. Ross NT, et al. Among authors: murphy j. Nat Chem Biol. 2020 Jan;16(1):50-59. doi: 10.1038/s41589-019-0424-1. Epub 2019 Dec 9. Nat Chem Biol. 2020. PMID: 31819276 Free PMC article.
Author Correction: CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma.
Ross NT, Lohmann F, Carbonneau S, Fazal A, Weihofen WA, Gleim S, Salcius M, Sigoillot F, Henault M, Carl SH, Rodríguez-Molina JB, Miller HR, Brittain SM, Murphy J, Zambrowski M, Boynton G, Wang Y, Chen A, Molind GJ, Wilbertz JH, Artus-Revel CG, Jia M, Akinjiyan FA, Turner J, Knehr J, Carbone W, Schuierer S, Reece-Hoyes JS, Xie K, Saran C, Williams ET, Roma G, Spencer M, Jenkins J, George EL, Thomas JR, Michaud G, Schirle M, Tallarico J, Passmore LA, Chao JA, Beckwith REJ. Ross NT, et al. Among authors: murphy j. Nat Chem Biol. 2020 Apr;16(4):479. doi: 10.1038/s41589-020-0508-y. Nat Chem Biol. 2020. PMID: 32139909
Chemoproteomics Enabled Discovery of Selective Probes for NuA4 Factor BRD8.
Remillard D, Savage NA, Kedves AT, Paulk J, Chen X, Garcia FJ, Romanowski MJ, Horton PA, Murphy J, Schirle M, Harrington EM, Maxwell MB, Pham HT, Maksimovic I, Thomas JR, Forrester WC. Remillard D, et al. Among authors: murphy j. ACS Chem Biol. 2021 Nov 19;16(11):2185-2192. doi: 10.1021/acschembio.1c00256. Epub 2021 Sep 13. ACS Chem Biol. 2021. PMID: 34515462
Discovery of Potent Pyrazoline-Based Covalent SARS-CoV-2 Main Protease Inhibitors.
Moon P, Zammit CM, Shao Q, Dovala D, Boike L, Henning NJ, Knapp M, Spradlin JN, Ward CC, Wolleb H, Fuller D, Blake G, Murphy JP, Wang F, Lu Y, Moquin SA, Tandeske L, Hesse MJ, McKenna JM, Tallarico JA, Schirle M, Toste FD, Nomura DK. Moon P, et al. Among authors: murphy jp. Chembiochem. 2023 Jun 1;24(11):e202300116. doi: 10.1002/cbic.202300116. Epub 2023 May 3. Chembiochem. 2023. PMID: 37069799
Enhancing the Small-Scale Screenable Biological Space beyond Known Chemogenomics Libraries with Gray Chemical Matter─Compounds with Novel Mechanisms from High-Throughput Screening Profiles.
Thomas JR, Shelton C 4th, Murphy J, Brittain S, Bray MA, Aspesi P, Concannon J, King FJ, Ihry RJ, Ho DJ, Henault M, Hadjikyriacou A, Neri M, Sigoillot FD, Pham HT, Shum M, Barys L, Jones MD, Martin EJ, Blechschmidt A, Rieffel S, Troxler TJ, Mapa FA, Jenkins JL, Jain RK, Kutchukian PS, Schirle M, Renner S. Thomas JR, et al. Among authors: murphy j. ACS Chem Biol. 2024 Apr 19;19(4):938-952. doi: 10.1021/acschembio.3c00737. Epub 2024 Apr 2. ACS Chem Biol. 2024. PMID: 38565185 Free PMC article.
7,588 results