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Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes.
Sockolosky JT, Trotta E, Parisi G, Picton L, Su LL, Le AC, Chhabra A, Silveria SL, George BM, King IC, Tiffany MR, Jude K, Sibener LV, Baker D, Shizuru JA, Ribas A, Bluestone JA, Garcia KC. Sockolosky JT, et al. Among authors: baker d. Science. 2018 Mar 2;359(6379):1037-1042. doi: 10.1126/science.aar3246. Science. 2018. PMID: 29496879 Free PMC article.
Designed protein logic to target cells with precise combinations of surface antigens.
Lajoie MJ, Boyken SE, Salter AI, Bruffey J, Rajan A, Langan RA, Olshefsky A, Muhunthan V, Bick MJ, Gewe M, Quijano-Rubio A, Johnson J, Lenz G, Nguyen A, Pun S, Correnti CE, Riddell SR, Baker D. Lajoie MJ, et al. Among authors: baker d. Science. 2020 Sep 25;369(6511):1637-1643. doi: 10.1126/science.aba6527. Epub 2020 Aug 20. Science. 2020. PMID: 32820060 Free PMC article.
Computationally designed protein activation.
Baker D. Baker D. Natl Sci Rev. 2019 Jul;6(4):609-610. doi: 10.1093/nsr/nwz063. Epub 2019 Jun 3. Natl Sci Rev. 2019. PMID: 34691911 Free PMC article. No abstract available.
Removing T-cell epitopes with computational protein design.
King C, Garza EN, Mazor R, Linehan JL, Pastan I, Pepper M, Baker D. King C, et al. Among authors: baker d. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8577-82. doi: 10.1073/pnas.1321126111. Epub 2014 May 19. Proc Natl Acad Sci U S A. 2014. PMID: 24843166 Free PMC article.
Principles for designing proteins with cavities formed by curved β sheets.
Marcos E, Basanta B, Chidyausiku TM, Tang Y, Oberdorfer G, Liu G, Swapna GV, Guan R, Silva DA, Dou J, Pereira JH, Xiao R, Sankaran B, Zwart PH, Montelione GT, Baker D. Marcos E, et al. Among authors: baker d. Science. 2017 Jan 13;355(6321):201-206. doi: 10.1126/science.aah7389. Science. 2017. PMID: 28082595 Free PMC article.
Protein structure determination using metagenome sequence data.
Ovchinnikov S, Park H, Varghese N, Huang PS, Pavlopoulos GA, Kim DE, Kamisetty H, Kyrpides NC, Baker D. Ovchinnikov S, et al. Among authors: baker d. Science. 2017 Jan 20;355(6322):294-298. doi: 10.1126/science.aah4043. Science. 2017. PMID: 28104891 Free PMC article.
De novo design of tunable, pH-driven conformational changes.
Boyken SE, Benhaim MA, Busch F, Jia M, Bick MJ, Choi H, Klima JC, Chen Z, Walkey C, Mileant A, Sahasrabuddhe A, Wei KY, Hodge EA, Byron S, Quijano-Rubio A, Sankaran B, King NP, Lippincott-Schwartz J, Wysocki VH, Lee KK, Baker D. Boyken SE, et al. Among authors: baker d. Science. 2019 May 17;364(6441):658-664. doi: 10.1126/science.aav7897. Science. 2019. PMID: 31097662 Free PMC article.
5,813 results