Kossiakoff A - Search Results

1

Rapid Discovery and Characterization of Synthetic Neutralizing Antibodies against Anthrax Edema Toxin.

Farcasanu M, Wang AG, Uchański T, Bailey LJ, Yue J, Chen Z, Wu X, Kossiakoff A, Tang WJ. Farcasanu M, et al. Among authors: kossiakoff a. Biochemistry. 2019 Jul 9;58(27):2996-3004. doi: 10.1021/acs.biochem.9b00184. Epub 2019 Jun 19. Biochemistry. 2019. PMID: 31243996 Free PMC article.

2

Dissecting the binding energy epitope of a high-affinity variant of human growth hormone: cooperative and additive effects from combining mutations from independently selected phage display mutagenesis libraries.

Bernat B, Sun M, Dwyer M, Feldkamp M, Kossiakoff AA. Bernat B, et al. Among authors: kossiakoff aa. Biochemistry. 2004 May 25;43(20):6076-84. doi: 10.1021/bi036069b. Biochemistry. 2004. PMID: 15147191

3

Applications for an engineered Protein-G variant with a pH controllable affinity to antibody fragments.

Bailey LJ, Sheehy KM, Hoey RJ, Schaefer ZP, Ura M, Kossiakoff AA. Bailey LJ, et al. Among authors: kossiakoff aa. J Immunol Methods. 2014 Dec 15;415:24-30. doi: 10.1016/j.jim.2014.10.003. Epub 2014 Oct 22. J Immunol Methods. 2014. PMID: 25450256 Free PMC article.

4

A polar ring endows improved specificity to an antibody fragment.

Schaefer ZP, Bailey LJ, Kossiakoff AA. Schaefer ZP, et al. Among authors: kossiakoff aa. Protein Sci. 2016 Jul;25(7):1290-8. doi: 10.1002/pro.2888. Epub 2016 Mar 9. Protein Sci. 2016. PMID: 27334407 Free PMC article.

5

Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination.

Bailey LJ, Sheehy KM, Dominik PK, Liang WG, Rui H, Clark M, Jaskolowski M, Kim Y, Deneka D, Tang WJ, Kossiakoff AA. Bailey LJ, et al. Among authors: kossiakoff aa. J Mol Biol. 2018 Feb 2;430(3):337-347. doi: 10.1016/j.jmb.2017.12.012. Epub 2017 Dec 19. J Mol Biol. 2018. PMID: 29273204 Free PMC article.

6

Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.

Zhang Z, Liang WG, Bailey LJ, Tan YZ, Wei H, Wang A, Farcasanu M, Woods VA, McCord LA, Lee D, Shang W, Deprez-Poulain R, Deprez B, Liu DR, Koide A, Koide S, Kossiakoff AA, Li S, Carragher B, Potter CS, Tang WJ. Zhang Z, et al. Among authors: kossiakoff aa. Elife. 2018 Mar 29;7:e33572. doi: 10.7554/eLife.33572. Elife. 2018. PMID: 29596046 Free PMC article.

7

An engineered ultra-high affinity Fab-Protein G pair enables a modular antibody platform with multifunctional capability.

Slezak T, Bailey LJ, Jaskolowski M, Nahotko DA, Filippova EV, Davydova EK, Kossiakoff AA. Slezak T, et al. Among authors: kossiakoff aa. Protein Sci. 2020 Jan;29(1):141-156. doi: 10.1002/pro.3751. Epub 2019 Nov 1. Protein Sci. 2020. PMID: 31622515 Free PMC article.

8

High affinity RNase S-peptide variants obtained by phage display have a novel "hot-spot" of binding energy.

Dwyer JJ, Dwyer MA, Kossiakoff AA. Dwyer JJ, et al. Among authors: kossiakoff aa. Biochemistry. 2001 Nov 13;40(45):13491-500. doi: 10.1021/bi011703b. Biochemistry. 2001. PMID: 11695896

9

The role of protein dynamics in increasing binding affinity for an engineered protein-protein interaction established by H/D exchange mass spectrometry.

Horn JR, Kraybill B, Petro EJ, Coales SJ, Morrow JA, Hamuro Y, Kossiakoff AA. Horn JR, et al. Among authors: kossiakoff aa. Biochemistry. 2006 Jul 18;45(28):8488-98. doi: 10.1021/bi0604328. Biochemistry. 2006. PMID: 16834322 Free article.

10

An engineered substance P variant for receptor-mediated delivery of synthetic antibodies into tumor cells.

Rizk SS, Luchniak A, Uysal S, Brawley CM, Rock RS, Kossiakoff AA. Rizk SS, et al. Among authors: kossiakoff aa. Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11011-5. doi: 10.1073/pnas.0904907106. Epub 2009 Jun 22. Proc Natl Acad Sci U S A. 2009. PMID: 19549879 Free PMC article.

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