Jiang H - Search Results

1

Discovery of novel CBP bromodomain inhibitors through TR-FRET-based high-throughput screening.

Zhang FC, Sun ZY, Liao LP, Zuo Y, Zhang D, Wang J, Chen YT, Xiao SH, Jiang H, Lu T, Xu P, Yue LY, Du DH, Zhang H, Liu CP, Luo C. Zhang FC, et al. Among authors: jiang h. Acta Pharmacol Sin. 2020 Feb;41(2):286-292. doi: 10.1038/s41401-019-0256-2. Epub 2019 Jun 28. Acta Pharmacol Sin. 2020. PMID: 31253937 Free PMC article.

2

Identification of Novel Inhibitors against Coactivator Associated Arginine Methyltransferase 1 Based on Virtual Screening and Biological Assays.

Ye F, Zhang W, Lu W, Xie Y, Jiang H, Jin J, Luo C. Ye F, et al. Among authors: jiang h. Biomed Res Int. 2016;2016:7086390. doi: 10.1155/2016/7086390. Epub 2016 Oct 27. Biomed Res Int. 2016. PMID: 27872854 Free PMC article.

3

Discovery of Novel Disruptor of Silencing Telomeric 1-Like (DOT1L) Inhibitors using a Target-Specific Scoring Function for the (S)-Adenosyl-l-methionine (SAM)-Dependent Methyltransferase Family.

Wang Y, Li L, Zhang B, Xing J, Chen S, Wan W, Song Y, Jiang H, Jiang H, Luo C, Zheng M. Wang Y, et al. Among authors: jiang h. J Med Chem. 2017 Mar 9;60(5):2026-2036. doi: 10.1021/acs.jmedchem.6b01785. Epub 2017 Feb 21. J Med Chem. 2017. PMID: 28165739

4

Discovery of novel BRD4 inhibitors by high-throughput screening, crystallography, and cell-based assays.

Sun Z, Zhang H, Chen Z, Xie Y, Jiang H, Chen L, Ding H, Zhang Y, Jiang H, Zheng M, Luo C. Sun Z, et al. Among authors: jiang h. Bioorg Med Chem Lett. 2017 May 1;27(9):2003-2009. doi: 10.1016/j.bmcl.2017.03.012. Epub 2017 Mar 9. Bioorg Med Chem Lett. 2017. PMID: 28347667

5

Discovery of alkyl bis(oxy)dibenzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors.

Zhang WY, Lu WC, Jiang H, Lv ZB, Xie YQ, Lian FL, Liang ZJ, Jiang YX, Wang DJ, Luo C, Jin J, Ye F. Zhang WY, et al. Among authors: jiang h, jiang yx. Chem Biol Drug Des. 2017 Dec;90(6):1260-1270. doi: 10.1111/cbdd.13047. Epub 2017 Jul 19. Chem Biol Drug Des. 2017. PMID: 28636189

6

Machine-Learning-Assisted Approach for Discovering Novel Inhibitors Targeting Bromodomain-Containing Protein 4.

Xing J, Lu W, Liu R, Wang Y, Xie Y, Zhang H, Shi Z, Jiang H, Liu YC, Chen K, Jiang H, Luo C, Zheng M. Xing J, et al. Among authors: jiang h. J Chem Inf Model. 2017 Jul 24;57(7):1677-1690. doi: 10.1021/acs.jcim.7b00098. Epub 2017 Jul 10. J Chem Inf Model. 2017. PMID: 28636361

7

Development of Potent Type I Protein Arginine Methyltransferase (PRMT) Inhibitors of Leukemia Cell Proliferation.

Wang C, Jiang H, Jin J, Xie Y, Chen Z, Zhang H, Lian F, Liu YC, Zhang C, Ding H, Chen S, Zhang N, Zhang Y, Jiang H, Chen K, Ye F, Yao Z, Luo C. Wang C, et al. Among authors: jiang h. J Med Chem. 2017 Nov 9;60(21):8888-8905. doi: 10.1021/acs.jmedchem.7b01134. Epub 2017 Oct 27. J Med Chem. 2017. PMID: 29019697

8

Discovery of novel BET inhibitors by drug repurposing of nitroxoline and its analogues.

Jiang H, Xing J, Wang C, Zhang H, Yue L, Wan X, Chen W, Ding H, Xie Y, Tao H, Chen Z, Jiang H, Chen K, Chen S, Zheng M, Zhang Y, Luo C. Jiang H, et al. Org Biomol Chem. 2017 Nov 15;15(44):9352-9361. doi: 10.1039/c7ob02369c. Org Biomol Chem. 2017. PMID: 29087414

9

Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral β-lactam bridged combretastatin A-4 analogues as potent antitumor agents.

Zhou P, Liang Y, Zhang H, Jiang H, Feng K, Xu P, Wang J, Wang X, Ding K, Luo C, Liu M, Wang Y. Zhou P, et al. Among authors: jiang h. Eur J Med Chem. 2018 Jan 20;144:817-842. doi: 10.1016/j.ejmech.2017.12.004. Epub 2017 Dec 7. Eur J Med Chem. 2018. PMID: 29306206

10

Computer-Aided Drug Design in Epigenetics.

Lu W, Zhang R, Jiang H, Zhang H, Luo C. Lu W, et al. Among authors: jiang h. Front Chem. 2018 Mar 12;6:57. doi: 10.3389/fchem.2018.00057. eCollection 2018. Front Chem. 2018. PMID: 29594101 Free PMC article. Review.

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