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Novel Dual-Target μ-Opioid Receptor and Dopamine D3 Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain Management.
Bonifazi A, Battiti FO, Sanchez J, Zaidi SA, Bow E, Makarova M, Cao J, Shaik AB, Sulima A, Rice KC, Katritch V, Canals M, Lane JR, Newman AH. Bonifazi A, et al. Among authors: battiti fo. J Med Chem. 2021 Jun 10;64(11):7778-7808. doi: 10.1021/acs.jmedchem.1c00611. Epub 2021 May 20. J Med Chem. 2021. PMID: 34011153 Free PMC article.
Chemical manipulations on the 1,4-dioxane ring of 5-HT1A receptor agonists lead to antagonists endowed with antitumor activity in prostate cancer cells.
Del Bello F, Bonifazi A, Giorgioni G, Quaglia W, Amantini C, Morelli MB, Santoni G, Battiti FO, Vistoli G, Cilia A, Piergentili A. Del Bello F, et al. Among authors: battiti fo. Eur J Med Chem. 2019 Apr 15;168:461-473. doi: 10.1016/j.ejmech.2019.02.056. Epub 2019 Feb 25. Eur J Med Chem. 2019. PMID: 30844609
A bitopic agonist bound to the dopamine 3 receptor reveals a selectivity site.
Arroyo-Urea S, Nazarova AL, Carrión-Antolí Á, Bonifazi A, Battiti FO, Lam JH, Newman AH, Katritch V, García-Nafría J. Arroyo-Urea S, et al. Among authors: battiti fo. Nat Commun. 2024 Sep 5;15(1):7759. doi: 10.1038/s41467-024-51993-4. Nat Commun. 2024. PMID: 39237617 Free PMC article.
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