Widness JA - Search Results

1

Target-mediated disposition population pharmacokinetics model of erythropoietin in premature neonates following multiple intravenous and subcutaneous dosing regimens.

D'Cunha R, Schmidt R, Widness JA, Mock DM, Yan X, Cress GA, Kuruvilla D, Veng-Pedersen P, An G. D'Cunha R, et al. Among authors: widness ja. Eur J Pharm Sci. 2019 Oct 1;138:105013. doi: 10.1016/j.ejps.2019.105013. Epub 2019 Jul 21. Eur J Pharm Sci. 2019. PMID: 31340188 Free PMC article. Clinical Trial.

2

Population Pharmacokinetics of Darbepoetin in Infants Following Single Intravenous and Subcutaneous Dosing.

An G, Ohls RK, Christensen RD, Widness JA, Mock DM, Veng-Pedersen P. An G, et al. Among authors: widness ja. J Pharm Sci. 2017 Jun;106(6):1644-1649. doi: 10.1016/j.xphs.2017.02.001. Epub 2017 Feb 9. J Pharm Sci. 2017. PMID: 28189627 Free PMC article. Clinical Trial.

3

Overlooked Issues on Pharmacokinetics Data Interpretation of Protein Drugs-a Case Example of Erythropoietin.

An G, Schmidt RL, Mock DM, Veng-Pedersen P, Widness JA. An G, et al. Among authors: widness ja. AAPS J. 2018 Nov 26;21(1):6. doi: 10.1208/s12248-018-0269-7. AAPS J. 2018. PMID: 30478521 Free PMC article. No abstract available.

4

A Mechanism-Based Population Pharmacokinetics Model of Erythropoietin in Premature Infants and Healthy Adults Following Multiple Intravenous Doses.

D'Cunha R, Widness JA, Yan X, Schmidt RL, Veng-Pedersen P, An G. D'Cunha R, et al. Among authors: widness ja. J Clin Pharmacol. 2019 Jun;59(6):835-846. doi: 10.1002/jcph.1368. Epub 2019 Jan 7. J Clin Pharmacol. 2019. PMID: 30618050 Free PMC article.

5

A Full Target-Mediated Drug Disposition (TMDD) Model to Explain the Changes in Recombinant Human Erythropoietin (rhEpo) Pharmacokinetics in Patients with Different Bone Marrow Integrity Following Hematopoietic Transplantation.

Wu N, Widness JA, Yan X, Veng-Pedersen P, An G. Wu N, et al. Among authors: widness ja. J Pharm Sci. 2022 Sep;111(9):2620-2629. doi: 10.1016/j.xphs.2022.06.003. Epub 2022 Jun 9. J Pharm Sci. 2022. PMID: 35691608 Free PMC article.

6

Increased erythropoietin elimination in fetal sheep following chronic phlebotomy.

Freise KJ, Widness JA, Segar JL, Schmidt RL, Veng-Pedersen P. Freise KJ, et al. Among authors: widness ja. Pharm Res. 2007 Sep;24(9):1653-9. doi: 10.1007/s11095-007-9295-3. Epub 2007 Apr 25. Pharm Res. 2007. PMID: 17457660 Free PMC article.

7

Pharmacokinetic differentiation of drug candidates using system analysis and physiological-based modelling. Comparison of C.E.R.A. and erythropoietin.

Veng-Pedersen P, Freise KJ, Schmidt RL, Widness JA. Veng-Pedersen P, et al. Among authors: widness ja. J Pharm Pharmacol. 2008 Oct;60(10):1321-34. doi: 10.1211/jpp/60.10.0008. J Pharm Pharmacol. 2008. PMID: 18812025 Free PMC article.

8

Erythropoietin pharmacokinetic/pharmacodynamic analysis suggests higher doses in treating neonatal anemia.

Neelakantan S, Widness JA, Schmidt RL, Veng-Pedersen P. Neelakantan S, et al. Among authors: widness ja. Pediatr Int. 2009 Feb;51(1):25-32. doi: 10.1111/j.1442-200X.2008.02648.x. Pediatr Int. 2009. PMID: 19371274 Free PMC article.

9

Pharmacokinetic analysis of continuous erythropoietin receptor activator disposition in adult sheep using a target-mediated, physiologic recirculation model and a tracer interaction methodology.

El-Komy MH, Widness JA, Veng-Pedersen P. El-Komy MH, et al. Among authors: widness ja. Drug Metab Dispos. 2011 Apr;39(4):603-9. doi: 10.1124/dmd.110.036236. Epub 2011 Jan 5. Drug Metab Dispos. 2011. PMID: 21209249 Free PMC article.

10

Pharmacodynamic analysis of stress erythropoiesis: change in erythropoietin receptor pool size following double phlebotomies in sheep.

Saleh MI, Widness JA, Veng-Pedersen P. Saleh MI, et al. Among authors: widness ja. Biopharm Drug Dispos. 2011 Apr;32(3):131-9. doi: 10.1002/bdd.743. Epub 2011 Jan 10. Biopharm Drug Dispos. 2011. PMID: 21456051 Free PMC article.

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