Johnson RM - Search Results

1

Emerging Role of Electron Microscopy in Drug Discovery.

Johnson RM, Higgins AJ, Muench SP. Johnson RM, et al. Trends Biochem Sci. 2019 Oct;44(10):897-898. doi: 10.1016/j.tibs.2019.07.003. Epub 2019 Aug 10. Trends Biochem Sci. 2019. PMID: 31409563 Free article. Review. No abstract available.

2

Approaches to altering particle distributions in cryo-electron microscopy sample preparation.

Drulyte I, Johnson RM, Hesketh EL, Hurdiss DL, Scarff CA, Porav SA, Ranson NA, Muench SP, Thompson RF. Drulyte I, et al. Among authors: johnson rm. Acta Crystallogr D Struct Biol. 2018 Jun 1;74(Pt 6):560-571. doi: 10.1107/S2059798318006496. Epub 2018 May 18. Acta Crystallogr D Struct Biol. 2018. PMID: 29872006 Free PMC article. Review.

3

Dimeric structures of quinol-dependent nitric oxide reductases (qNORs) revealed by cryo-electron microscopy.

Gopalasingam CC, Johnson RM, Chiduza GN, Tosha T, Yamamoto M, Shiro Y, Antonyuk SV, Muench SP, Hasnain SS. Gopalasingam CC, et al. Among authors: johnson rm. Sci Adv. 2019 Aug 28;5(8):eaax1803. doi: 10.1126/sciadv.aax1803. eCollection 2019 Aug. Sci Adv. 2019. PMID: 31489376 Free PMC article.

4

The Growing Role of Electron Microscopy in Anti-parasitic Drug Discovery.

Johnson RM, Rawson S, McPhillie MJ, Fishwick CWG, Muench SP. Johnson RM, et al. Curr Med Chem. 2018;25(39):5279-5290. doi: 10.2174/0929867324666171109120526. Curr Med Chem. 2018. PMID: 29119913 Free article. Review.

5

X-ray and cryo-EM structures of inhibitor-bound cytochrome bc₁ complexes for structure-based drug discovery.

Amporndanai K, Johnson RM, O'Neill PM, Fishwick CWG, Jamson AH, Rawson S, Muench SP, Hasnain SS, Antonyuk SV. Amporndanai K, et al. Among authors: johnson rm. IUCrJ. 2018 Feb 20;5(Pt 2):200-210. doi: 10.1107/S2052252518001616. eCollection 2018 Mar 1. IUCrJ. 2018. PMID: 29765610 Free PMC article.

6

LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM.

Chiduza GN, Johnson RM, Wright GSA, Antonyuk SV, Muench SP, Hasnain SS. Chiduza GN, et al. Among authors: johnson rm. Acta Crystallogr D Struct Biol. 2019 Jul 1;75(Pt 7):660-669. doi: 10.1107/S2059798319009094. Epub 2019 Jun 28. Acta Crystallogr D Struct Biol. 2019. PMID: 31282475 Free PMC article.

7

The potential use of single-particle electron microscopy as a tool for structure-based inhibitor design.

Rawson S, McPhillie MJ, Johnson RM, Fishwick CWG, Muench SP. Rawson S, et al. Among authors: johnson rm. Acta Crystallogr D Struct Biol. 2017 Jun 1;73(Pt 6):534-540. doi: 10.1107/S2059798317004077. Epub 2017 Apr 20. Acta Crystallogr D Struct Biol. 2017. PMID: 28580915 Free PMC article.

8

Human TRPC5 structures reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site.

Wright DJ, Simmons KJ, Johnson RM, Beech DJ, Muench SP, Bon RS. Wright DJ, et al. Among authors: johnson rm. Commun Biol. 2020 Nov 23;3(1):704. doi: 10.1038/s42003-020-01437-8. Commun Biol. 2020. PMID: 33230284 Free PMC article.

9

Structure-Based Identification and Characterization of Inhibitors of the Epilepsy-Associated K_Na1.1 (KCNT1) Potassium Channel.

Cole BA, Johnson RM, Dejakaisaya H, Pilati N, Fishwick CWG, Muench SP, Lippiat JD. Cole BA, et al. Among authors: johnson rm. iScience. 2020 May 22;23(5):101100. doi: 10.1016/j.isci.2020.101100. Epub 2020 Apr 25. iScience. 2020. PMID: 32408169 Free PMC article.

10

The active form of quinol-dependent nitric oxide reductase from Neisseria meningitidis is a dimer.

Jamali MAM, Gopalasingam CC, Johnson RM, Tosha T, Muramoto K, Muench SP, Antonyuk SV, Shiro Y, Hasnain SS. Jamali MAM, et al. Among authors: johnson rm. IUCrJ. 2020 Mar 21;7(Pt 3):404-415. doi: 10.1107/S2052252520003656. eCollection 2020 May 1. IUCrJ. 2020. PMID: 32431824 Free PMC article.

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