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Page 1
A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster.
Lang S, Hilsabeck TA, Wilson KA, Sharma A, Bose N, Brackman DJ, Beck JN, Chen L, Watson MA, Killilea DW, Ho S, Kahn A, Giacomini K, Stoller ML, Chi T, Kapahi P. Lang S, et al. Among authors: hilsabeck ta. PLoS Genet. 2019 Aug 15;15(8):e1008318. doi: 10.1371/journal.pgen.1008318. eCollection 2019 Aug. PLoS Genet. 2019. PMID: 31415568 Free PMC article.
S3QELs protect against diet-induced intestinal barrier dysfunction.
Watson MA, Pattavina B, Hilsabeck TAU, Lopez-Dominguez J, Kapahi P, Brand MD. Watson MA, et al. Among authors: hilsabeck tau. Aging Cell. 2021 Oct;20(10):e13476. doi: 10.1111/acel.13476. Epub 2021 Sep 14. Aging Cell. 2021. PMID: 34521156 Free PMC article.
A fly GWAS for purine metabolites identifies human FAM214 homolog medusa, which acts in a conserved manner to enhance hyperuricemia-driven pathologies by modulating purine metabolism and the inflammatory response.
Hilsabeck TAU, Liu-Bryan R, Guo T, Wilson KA, Bose N, Raftery D, Beck JN, Lang S, Jin K, Nelson CS, Oron T, Stoller M, Promislow D, Brem RB, Terkeltaub R, Kapahi P. Hilsabeck TAU, et al. Geroscience. 2022 Aug;44(4):2195-2211. doi: 10.1007/s11357-022-00557-9. Epub 2022 Apr 6. Geroscience. 2022. PMID: 35381951 Free PMC article.
Systems biology and machine learning approaches identify metabolites that influence dietary lifespan and healthspan responses across flies and humans.
Hilsabeck TAU, Narayan VP, Wilson KA, Carrera E, Raftery D, Promislow D, Brem RB, Campisi J, Kapahi P. Hilsabeck TAU, et al. bioRxiv [Preprint]. 2023 Dec 4:2023.07.09.548232. doi: 10.1101/2023.07.09.548232. bioRxiv. 2023. Update in: Nat Commun. 2024 Oct 29;15(1):9330. doi: 10.1038/s41467-024-52909-y PMID: 37503266 Free PMC article. Updated. Preprint.
Neuronal Glycogen Breakdown Mitigates Tauopathy via Pentose Phosphate Pathway-Mediated Oxidative Stress Reduction.
Bar S, Wilson KA, Hilsabeck TAU, Alderfer S, Dammer EB, Burton JB, Shah S, Holtz A, Carrera EM, Beck JN, Chen JH, Kauwe G, Tracy TE, Seyfried NT, Schilling B, Ellerby LM, Kapahi P. Bar S, et al. Among authors: hilsabeck tau. Res Sq [Preprint]. 2023 Nov 8:rs.3.rs-3526342. doi: 10.21203/rs.3.rs-3526342/v1. Res Sq. 2023. PMID: 37986935 Free PMC article. Preprint.
OXR1 maintains the retromer to delay brain aging under dietary restriction.
Wilson KA, Bar S, Dammer EB, Carrera EM, Hodge BA, Hilsabeck TAU, Bons J, Brownridge GW 3rd, Beck JN, Rose J, Granath-Panelo M, Nelson CS, Qi G, Gerencser AA, Lan J, Afenjar A, Chawla G, Brem RB, Campeau PM, Bellen HJ, Schilling B, Seyfried NT, Ellerby LM, Kapahi P. Wilson KA, et al. Among authors: hilsabeck tau. Nat Commun. 2024 Jan 11;15(1):467. doi: 10.1038/s41467-023-44343-3. Nat Commun. 2024. PMID: 38212606 Free PMC article.
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