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VHH characterization. Comparison of recombinant with chemically synthesized anti-HER2 VHH.
Hartmann L, Botzanowski T, Galibert M, Jullian M, Chabrol E, Zeder-Lutz G, Kugler V, Stojko J, Strub JM, Ferry G, Frankiewicz L, Puget K, Wagner R, Cianférani S, Boutin JA. Hartmann L, et al. Among authors: cianferani s. Protein Sci. 2019 Oct;28(10):1865-1879. doi: 10.1002/pro.3712. Epub 2019 Aug 29. Protein Sci. 2019. PMID: 31423659 Free PMC article.
Soaking suggests "alternative facts": Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibition.
Ehrmann FR, Stojko J, Metz A, Debaene F, Barandun LJ, Heine A, Diederich F, Cianférani S, Reuter K, Klebe G. Ehrmann FR, et al. Among authors: cianferani s. PLoS One. 2017 Apr 18;12(4):e0175723. doi: 10.1371/journal.pone.0175723. eCollection 2017. PLoS One. 2017. PMID: 28419165 Free PMC article.
189 results