Fujishige K - Search Results

1

8-(3-chloro-4-methoxybenzyl)-8H-pyrido[2,3-d]pyrimidin-7-one derivatives as potent and selective phosphodiesterase 5 inhibitors.

Sakamoto T, Koga Y, Hikota M, Matsuki K, Mochida H, Kikkawa K, Fujishige K, Kotera J, Omori K, Morimoto H, Yamada K. Sakamoto T, et al. Among authors: fujishige k. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1431-5. doi: 10.1016/j.bmcl.2015.02.041. Epub 2015 Feb 21. Bioorg Med Chem Lett. 2015. PMID: 25754491

2

The discovery of avanafil for the treatment of erectile dysfunction: a novel pyrimidine-5-carboxamide derivative as a potent and highly selective phosphodiesterase 5 inhibitor.

Sakamoto T, Koga Y, Hikota M, Matsuki K, Murakami M, Kikkawa K, Fujishige K, Kotera J, Omori K, Morimoto H, Yamada K. Sakamoto T, et al. Among authors: fujishige k. Bioorg Med Chem Lett. 2014 Dec 1;24(23):5460-5. doi: 10.1016/j.bmcl.2014.10.008. Epub 2014 Oct 28. Bioorg Med Chem Lett. 2014. PMID: 25455484

3

Design and synthesis of novel 5-(3,4,5-trimethoxybenzoyl)-4-aminopyrimidine derivatives as potent and selective phosphodiesterase 5 inhibitors: scaffold hopping using a pseudo-ring by intramolecular hydrogen bond formation.

Sakamoto T, Koga Y, Hikota M, Matsuki K, Murakami M, Kikkawa K, Fujishige K, Kotera J, Omori K, Morimoto H, Yamada K. Sakamoto T, et al. Among authors: fujishige k. Bioorg Med Chem Lett. 2014 Nov 15;24(22):5175-80. doi: 10.1016/j.bmcl.2014.09.082. Epub 2014 Oct 2. Bioorg Med Chem Lett. 2014. PMID: 25442307

4

Robust in vitro affinity maturation strategy based on interface-focused high-throughput mutational scanning.

Fujino Y, Fujita R, Wada K, Fujishige K, Kanamori T, Hunt L, Shimizu Y, Ueda T. Fujino Y, et al. Among authors: fujishige k. Biochem Biophys Res Commun. 2012 Nov 23;428(3):395-400. doi: 10.1016/j.bbrc.2012.10.066. Epub 2012 Oct 26. Biochem Biophys Res Commun. 2012. PMID: 23103372

5

Avanafil, a potent and highly selective phosphodiesterase-5 inhibitor for erectile dysfunction.

Kotera J, Mochida H, Inoue H, Noto T, Fujishige K, Sasaki T, Kobayashi T, Kojima K, Yee S, Yamada Y, Kikkawa K, Omori K. Kotera J, et al. Among authors: fujishige k. J Urol. 2012 Aug;188(2):668-74. doi: 10.1016/j.juro.2012.03.115. Epub 2012 Jun 15. J Urol. 2012. PMID: 22704456

6

Highly sensitive cell-based assay system to monitor the sialyl Lewis X biosynthesis mediated by alpha1-3 fucosyltransferase-VII.

Miyashiro M, Furuya S, Fujishige K, Sugita T. Miyashiro M, et al. Among authors: fujishige k. Biochem Biophys Res Commun. 2004 Nov 5;324(1):98-107. doi: 10.1016/j.bbrc.2004.09.025. Biochem Biophys Res Commun. 2004. PMID: 15464988

7

Subcellular localization of cyclic nucleotide phosphodiesterase type 10A variants, and alteration of the localization by cAMP-dependent protein kinase-dependent phosphorylation.

Kotera J, Sasaki T, Kobayashi T, Fujishige K, Yamashita Y, Omori K. Kotera J, et al. Among authors: fujishige k. J Biol Chem. 2004 Feb 6;279(6):4366-75. doi: 10.1074/jbc.M308471200. Epub 2003 Nov 6. J Biol Chem. 2004. PMID: 14604994 Free article.

8

1,7- and 2,7-naphthyridine derivatives as potent and highly specific PDE5 inhibitors.

Ukita T, Nakamura Y, Kubo A, Yamamoto Y, Moritani Y, Saruta K, Higashijima T, Kotera J, Fujishige K, Takagi M, Kikkawa K, Omori K. Ukita T, et al. Among authors: fujishige k. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2341-5. doi: 10.1016/s0960-894x(03)00440-2. Bioorg Med Chem Lett. 2003. PMID: 12824030

9

Enzymological and pharmacological profile of T-0156, a potent and selective phosphodiesterase type 5 inhibitor.

Mochida H, Takagi M, Inoue H, Noto T, Yano K, Fujishige K, Sasaki T, Yuasa K, Kotera J, Omori K, Kikkawa K. Mochida H, et al. Among authors: fujishige k. Eur J Pharmacol. 2002 Dec 5;456(1-3):91-8. doi: 10.1016/s0014-2999(02)02590-6. Eur J Pharmacol. 2002. PMID: 12450574

10

Characterization and effects of methyl-2- (4-aminophenyl)-1, 2-dihydro-1-oxo-7- (2-pyridinylmethoxy)-4-(3,4, 5-trimethoxyphenyl)-3-isoquinoline carboxylate sulfate (T-1032), a novel potent inhibitor of cGMP-binding cGMP-specific phosphodiesterase (PDE5).

Kotera J, Fujishige K, Michibata H, Yuasa K, Kubo A, Nakamura Y, Omori K. Kotera J, et al. Among authors: fujishige k. Biochem Pharmacol. 2000 Nov 1;60(9):1333-41. doi: 10.1016/s0006-2952(00)00457-3. Biochem Pharmacol. 2000. PMID: 11008127

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