Caffrey CR - Search Results

1

Benzimidazole inhibitors of the major cysteine protease of Trypanosoma brucei.

Pereira GA, Santos LH, Wang SC, Martins LC, Villela FS, Liao W, Dessoy MA, Dias LC, Andricopulo AD, Costa MA, Nagem RA, Caffrey CR, Liedl KR, Caffarena ER, Ferreira RS. Pereira GA, et al. Among authors: caffrey cr. Future Med Chem. 2019 Jul;11(13):1537-1551. doi: 10.4155/fmc-2018-0523. Future Med Chem. 2019. PMID: 31469332 Free PMC article.

2

Cysteine protease inhibitors as chemotherapy for parasitic infections.

McKerrow JH, Engel JC, Caffrey CR. McKerrow JH, et al. Among authors: caffrey cr. Bioorg Med Chem. 1999 Apr;7(4):639-44. doi: 10.1016/s0968-0896(99)00008-5. Bioorg Med Chem. 1999. PMID: 10353643 Review.

3

Aryl ureas represent a new class of anti-trypanosomal agents.

Du X, Hansell E, Engel JC, Caffrey CR, Cohen FE, McKerrow JH. Du X, et al. Among authors: caffrey cr. Chem Biol. 2000 Sep;7(9):733-42. doi: 10.1016/s1074-5521(00)00018-1. Chem Biol. 2000. PMID: 10980453

4

Screening of acyl hydrazide proteinase inhibitors for antiparasitic activity against Trypanosoma brucei.

Caffrey CR, Schanz M, Nkemngu NJ, Brush M, Hansell E, Cohen FE, Flaherty TM, McKerrow JH, Steverding D. Caffrey CR, et al. Int J Antimicrob Agents. 2002 Mar;19(3):227-31. doi: 10.1016/s0924-8579(01)00488-5. Int J Antimicrob Agents. 2002. PMID: 11932146

5

Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain.

Du X, Guo C, Hansell E, Doyle PS, Caffrey CR, Holler TP, McKerrow JH, Cohen FE. Du X, et al. Among authors: caffrey cr. J Med Chem. 2002 Jun 20;45(13):2695-707. doi: 10.1021/jm010459j. J Med Chem. 2002. PMID: 12061873

6

Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.

Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K. Greenbaum DC, et al. Among authors: caffrey cr. J Med Chem. 2004 Jun 3;47(12):3212-9. doi: 10.1021/jm030549j. J Med Chem. 2004. PMID: 15163200

7

Peptidyl allyl sulfones: a new class of inhibitors for clan CA cysteine proteases.

Götz MG, Caffrey CR, Hansell E, McKerrow JH, Powers JC. Götz MG, et al. Among authors: caffrey cr. Bioorg Med Chem. 2004 Oct 1;12(19):5203-11. doi: 10.1016/j.bmc.2004.07.016. Bioorg Med Chem. 2004. PMID: 15351403

8

Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents.

Vicik R, Hoerr V, Glaser M, Schultheis M, Hansell E, McKerrow JH, Holzgrabe U, Caffrey CR, Ponte-Sucre A, Moll H, Stich A, Schirmeister T. Vicik R, et al. Among authors: caffrey cr. Bioorg Med Chem Lett. 2006 May 15;16(10):2753-7. doi: 10.1016/j.bmcl.2006.02.026. Epub 2006 Mar 3. Bioorg Med Chem Lett. 2006. PMID: 16516467

9

Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB.

Mallari JP, Shelat AA, Obrien T, Caffrey CR, Kosinski A, Connelly M, Harbut M, Greenbaum D, McKerrow JH, Guy RK. Mallari JP, et al. Among authors: caffrey cr. J Med Chem. 2008 Feb 14;51(3):545-52. doi: 10.1021/jm070760l. Epub 2008 Jan 4. J Med Chem. 2008. PMID: 18173229

10

Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB.

Mallari JP, Shelat A, Kosinski A, Caffrey CR, Connelly M, Zhu F, McKerrow JH, Guy RK. Mallari JP, et al. Among authors: caffrey cr. Bioorg Med Chem Lett. 2008 May 1;18(9):2883-5. doi: 10.1016/j.bmcl.2008.03.083. Epub 2008 Apr 8. Bioorg Med Chem Lett. 2008. PMID: 18420405 Free PMC article.

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