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The remote allosteric control of Orai channel gating.
Zhou Y, Nwokonko RM, Baraniak JH Jr, Trebak M, Lee KPK, Gill DL. Zhou Y, et al. Among authors: nwokonko rm. PLoS Biol. 2019 Aug 30;17(8):e3000413. doi: 10.1371/journal.pbio.3000413. eCollection 2019 Aug. PLoS Biol. 2019. PMID: 31469825 Free PMC article.
STIM1 dimers undergo unimolecular coupling to activate Orai1 channels.
Zhou Y, Wang X, Wang X, Loktionova NA, Cai X, Nwokonko RM, Vrana E, Wang Y, Rothberg BS, Gill DL. Zhou Y, et al. Among authors: nwokonko rm. Nat Commun. 2015 Sep 24;6:8395. doi: 10.1038/ncomms9395. Nat Commun. 2015. PMID: 26399906 Free PMC article.
The Orai1 Store-operated Calcium Channel Functions as a Hexamer.
Cai X, Zhou Y, Nwokonko RM, Loktionova NA, Wang X, Xin P, Trebak M, Wang Y, Gill DL. Cai X, et al. Among authors: nwokonko rm. J Biol Chem. 2016 Dec 9;291(50):25764-25775. doi: 10.1074/jbc.M116.758813. Epub 2016 Oct 25. J Biol Chem. 2016. PMID: 27780862 Free PMC article.
The STIM1-binding site nexus remotely controls Orai1 channel gating.
Zhou Y, Cai X, Loktionova NA, Wang X, Nwokonko RM, Wang X, Wang Y, Rothberg BS, Trebak M, Gill DL. Zhou Y, et al. Among authors: nwokonko rm. Nat Commun. 2016 Dec 8;7:13725. doi: 10.1038/ncomms13725. Nat Commun. 2016. PMID: 27929067 Free PMC article.
The STIM-Orai coupling interface and gating of the Orai1 channel.
Zhou Y, Cai X, Nwokonko RM, Loktionova NA, Wang Y, Gill DL. Zhou Y, et al. Among authors: nwokonko rm. Cell Calcium. 2017 May;63:8-13. doi: 10.1016/j.ceca.2017.01.001. Epub 2017 Jan 8. Cell Calcium. 2017. PMID: 28087079 Free PMC article. Review.
Cross-linking of Orai1 channels by STIM proteins.
Zhou Y, Nwokonko RM, Cai X, Loktionova NA, Abdulqadir R, Xin P, Niemeyer BA, Wang Y, Trebak M, Gill DL. Zhou Y, et al. Among authors: nwokonko rm. Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3398-E3407. doi: 10.1073/pnas.1720810115. Epub 2018 Mar 26. Proc Natl Acad Sci U S A. 2018. PMID: 29581306 Free PMC article.
20 results