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Multi-omic biomarker identification and validation for diagnosing warzone-related post-traumatic stress disorder.
Dean KR, Hammamieh R, Mellon SH, Abu-Amara D, Flory JD, Guffanti G, Wang K, Daigle BJ Jr, Gautam A, Lee I, Yang R, Almli LM, Bersani FS, Chakraborty N, Donohue D, Kerley K, Kim TK, Laska E, Young Lee M, Lindqvist D, Lori A, Lu L, Misganaw B, Muhie S, Newman J, Price ND, Qin S, Reus VI, Siegel C, Somvanshi PR, Thakur GS, Zhou Y; PTSD Systems Biology Consortium; Hood L, Ressler KJ, Wolkowitz OM, Yehuda R, Jett M, Doyle FJ 3rd, Marmar C. Dean KR, et al. Among authors: guffanti g. Mol Psychiatry. 2020 Dec;25(12):3337-3349. doi: 10.1038/s41380-019-0496-z. Epub 2019 Sep 10. Mol Psychiatry. 2020. PMID: 31501510 Free PMC article.
A genome-wide association study of post-traumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus.
Logue MW, Baldwin C, Guffanti G, Melista E, Wolf EJ, Reardon AF, Uddin M, Wildman D, Galea S, Koenen KC, Miller MW. Logue MW, et al. Among authors: guffanti g. Mol Psychiatry. 2013 Aug;18(8):937-42. doi: 10.1038/mp.2012.113. Epub 2012 Aug 7. Mol Psychiatry. 2013. PMID: 22869035 Free PMC article.
Genome-wide association study implicates a novel RNA gene, the lincRNA AC068718.1, as a risk factor for post-traumatic stress disorder in women.
Guffanti G, Galea S, Yan L, Roberts AL, Solovieff N, Aiello AE, Smoller JW, De Vivo I, Ranu H, Uddin M, Wildman DE, Purcell S, Koenen KC. Guffanti G, et al. Psychoneuroendocrinology. 2013 Dec;38(12):3029-38. doi: 10.1016/j.psyneuen.2013.08.014. Epub 2013 Sep 8. Psychoneuroendocrinology. 2013. PMID: 24080187 Free PMC article.
No association between RORA polymorphisms and PTSD in two independent samples.
Guffanti G, Ashley-Koch AE, Roberts AL, Garrett ME, Solovieff N, Ratanatharathorn A, De Vivo I, Dennis M, Ranu H, Smoller JW, Liu Y, Purcell SM; Veterans Affairs Mid-Atlantic Mental Illness Research, Education, and Clinical Center Workgroup; Beckham J, Hauser MA, Koenen KC. Guffanti G, et al. Mol Psychiatry. 2014 Oct;19(10):1056-7. doi: 10.1038/mp.2014.19. Epub 2014 Jul 22. Mol Psychiatry. 2014. PMID: 25048002 No abstract available.
Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability.
Duncan LE, Ratanatharathorn A, Aiello AE, Almli LM, Amstadter AB, Ashley-Koch AE, Baker DG, Beckham JC, Bierut LJ, Bisson J, Bradley B, Chen CY, Dalvie S, Farrer LA, Galea S, Garrett ME, Gelernter JE, Guffanti G, Hauser MA, Johnson EO, Kessler RC, Kimbrel NA, King A, Koen N, Kranzler HR, Logue MW, Maihofer AX, Martin AR, Miller MW, Morey RA, Nugent NR, Rice JP, Ripke S, Roberts AL, Saccone NL, Smoller JW, Stein DJ, Stein MB, Sumner JA, Uddin M, Ursano RJ, Wildman DE, Yehuda R, Zhao H, Daly MJ, Liberzon I, Ressler KJ, Nievergelt CM, Koenen KC. Duncan LE, et al. Among authors: guffanti g. Mol Psychiatry. 2018 Mar;23(3):666-673. doi: 10.1038/mp.2017.77. Epub 2017 Apr 25. Mol Psychiatry. 2018. PMID: 28439101 Free PMC article.
Epigenome-wide association of PTSD from heterogeneous cohorts with a common multi-site analysis pipeline.
Ratanatharathorn A, Boks MP, Maihofer AX, Aiello AE, Amstadter AB, Ashley-Koch AE, Baker DG, Beckham JC, Bromet E, Dennis M, Garrett ME, Geuze E, Guffanti G, Hauser MA, Kilaru V, Kimbrel NA, Koenen KC, Kuan PF, Logue MW, Luft BJ, Miller MW, Mitchell C, Nugent NR, Ressler KJ, Rutten BPF, Stein MB, Vermetten E, Vinkers CH, Youssef NA; VA Mid-Atlantic MIRECC Workgroup; PGC PTSD Epigenetics Workgroup; Uddin M, Nievergelt CM, Smith AK. Ratanatharathorn A, et al. Among authors: guffanti g. Am J Med Genet B Neuropsychiatr Genet. 2017 Sep;174(6):619-630. doi: 10.1002/ajmg.b.32568. Epub 2017 Jul 10. Am J Med Genet B Neuropsychiatr Genet. 2017. PMID: 28691784 Free PMC article.
67 results