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A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model.
Yant SR, Mulato A, Hansen D, Tse WC, Niedziela-Majka A, Zhang JR, Stepan GJ, Jin D, Wong MH, Perreira JM, Singer E, Papalia GA, Hu EY, Zheng J, Lu B, Schroeder SD, Chou K, Ahmadyar S, Liclican A, Yu H, Novikov N, Paoli E, Gonik D, Ram RR, Hung M, McDougall WM, Brass AL, Sundquist WI, Cihlar T, Link JO. Yant SR, et al. Among authors: brass al. Nat Med. 2019 Sep;25(9):1377-1384. doi: 10.1038/s41591-019-0560-x. Epub 2019 Sep 9. Nat Med. 2019. PMID: 31501601 Free PMC article.
IFITMs restrict the replication of multiple pathogenic viruses.
Perreira JM, Chin CR, Feeley EM, Brass AL. Perreira JM, et al. Among authors: brass al. J Mol Biol. 2013 Dec 13;425(24):4937-55. doi: 10.1016/j.jmb.2013.09.024. Epub 2013 Sep 25. J Mol Biol. 2013. PMID: 24076421 Free PMC article. Review.
The IFITMs Inhibit Zika Virus Replication.
Savidis G, Perreira JM, Portmann JM, Meraner P, Guo Z, Green S, Brass AL. Savidis G, et al. Among authors: brass al. Cell Rep. 2016 Jun 14;15(11):2323-30. doi: 10.1016/j.celrep.2016.05.074. Epub 2016 Jun 3. Cell Rep. 2016. PMID: 27268505 Free article.
Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.
Savidis G, McDougall WM, Meraner P, Perreira JM, Portmann JM, Trincucci G, John SP, Aker AM, Renzette N, Robbins DR, Guo Z, Green S, Kowalik TF, Brass AL. Savidis G, et al. Among authors: brass al. Cell Rep. 2016 Jun 28;16(1):232-246. doi: 10.1016/j.celrep.2016.06.028. Epub 2016 Jun 21. Cell Rep. 2016. PMID: 27342126 Free article.
CRISPR genetic screens to discover host-virus interactions.
McDougall WM, Perreira JM, Reynolds EC, Brass AL. McDougall WM, et al. Among authors: brass al. Curr Opin Virol. 2018 Apr;29:87-100. doi: 10.1016/j.coviro.2018.03.007. Curr Opin Virol. 2018. PMID: 29684735 Review.
54 results