Longley DB - Search Results

1

Heterogeneous responses to low level death receptor activation are explained by random molecular assembly of the Caspase-8 activation platform.

Matveeva A, Fichtner M, McAllister K, McCann C, Sturrock M, Longley DB, Prehn JHM. Matveeva A, et al. Among authors: longley db. PLoS Comput Biol. 2019 Sep 25;15(9):e1007374. doi: 10.1371/journal.pcbi.1007374. eCollection 2019 Sep. PLoS Comput Biol. 2019. PMID: 31553717 Free PMC article.

2

c-FLIP: a key regulator of colorectal cancer cell death.

Wilson TR, McLaughlin KM, McEwan M, Sakai H, Rogers KM, Redmond KM, Johnston PG, Longley DB. Wilson TR, et al. Among authors: longley db. Cancer Res. 2007 Jun 15;67(12):5754-62. doi: 10.1158/0008-5472.CAN-06-3585. Cancer Res. 2007. PMID: 17575142 Free article.

3

Anti-apoptotic mechanisms of drug resistance in cancer.

Wilson TR, Johnston PG, Longley DB. Wilson TR, et al. Among authors: longley db. Curr Cancer Drug Targets. 2009 May;9(3):307-19. doi: 10.2174/156800909788166547. Curr Cancer Drug Targets. 2009. PMID: 19442051 Review.

4

Voltage dependent anion channel-1 regulates death receptor mediated apoptosis by enabling cleavage of caspase-8.

Chacko AD, Liberante F, Paul I, Longley DB, Fennell DA. Chacko AD, et al. Among authors: longley db. BMC Cancer. 2010 Jul 20;10:380. doi: 10.1186/1471-2407-10-380. BMC Cancer. 2010. PMID: 20646307 Free PMC article.

5

Acquired differential regulation of caspase-8 in cisplatin-resistant non-small-cell lung cancer.

Paul I, Chacko AD, Stasik I, Busacca S, Crawford N, McCoy F, McTavish N, Wilson B, Barr M, O'Byrne KJ, Longley DB, Fennell DA. Paul I, et al. Among authors: longley db. Cell Death Dis. 2012 Dec 20;3(12):e449. doi: 10.1038/cddis.2012.186. Cell Death Dis. 2012. PMID: 23254292 Free PMC article.

6

Differential affinity of FLIP and procaspase 8 for FADD's DED binding surfaces regulates DISC assembly.

Majkut J, Sgobba M, Holohan C, Crawford N, Logan AE, Kerr E, Higgins CA, Redmond KL, Riley JS, Stasik I, Fennell DA, Van Schaeybroeck S, Haider S, Johnston PG, Haigh D, Longley DB. Majkut J, et al. Among authors: longley db. Nat Commun. 2014 Feb 28;5:3350. doi: 10.1038/ncomms4350. Nat Commun. 2014. PMID: 24577104 Free PMC article.

7

DED or alive: assembly and regulation of the death effector domain complexes.

Riley JS, Malik A, Holohan C, Longley DB. Riley JS, et al. Among authors: longley db. Cell Death Dis. 2015 Aug 27;6(8):e1866. doi: 10.1038/cddis.2015.213. Cell Death Dis. 2015. PMID: 26313917 Free PMC article. Review.

8

PTEN deficiency promotes macrophage infiltration and hypersensitivity of prostate cancer to IAP antagonist/radiation combination therapy.

Armstrong CW, Maxwell PJ, Ong CW, Redmond KM, McCann C, Neisen J, Ward GA, Chessari G, Johnson C, Crawford NT, LaBonte MJ, Prise KM, Robson T, Salto-Tellez M, Longley DB, Waugh DJ. Armstrong CW, et al. Among authors: longley db. Oncotarget. 2016 Feb 16;7(7):7885-98. doi: 10.18632/oncotarget.6955. Oncotarget. 2016. PMID: 26799286 Free PMC article.

9

A Stepwise Integrated Approach to Personalized Risk Predictions in Stage III Colorectal Cancer.

Salvucci M, Würstle ML, Morgan C, Curry S, Cremona M, Lindner AU, Bacon O, Resler AJ, Murphy ÁC, O'Byrne R, Flanagan L, Dasgupta S, Rice N, Pilati C, Zink E, Schöller LM, Toomey S, Lawler M, Johnston PG, Wilson R, Camilleri-Broët S, Salto-Tellez M, McNamara DA, Kay EW, Laurent-Puig P, Van Schaeybroeck S, Hennessy BT, Longley DB, Rehm M, Prehn JH. Salvucci M, et al. Among authors: longley db. Clin Cancer Res. 2017 Mar 1;23(5):1200-1212. doi: 10.1158/1078-0432.CCR-16-1084. Epub 2016 Sep 20. Clin Cancer Res. 2017. PMID: 27649552

10

Simulating and predicting cellular and in vivo responses of colon cancer to combined treatment with chemotherapy and IAP antagonist Birinapant/TL32711.

Crawford N, Salvucci M, Hellwig CT, Lincoln FA, Mooney RE, O'Connor CL, Prehn JH, Longley DB, Rehm M. Crawford N, et al. Among authors: longley db. Cell Death Differ. 2018 Nov;25(11):1952-1966. doi: 10.1038/s41418-018-0082-y. Epub 2018 Mar 2. Cell Death Differ. 2018. PMID: 29500433 Free PMC article.

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