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Smg1 haploinsufficiency predisposes to tumor formation and inflammation.
Roberts TL, Ho U, Luff J, Lee CS, Apte SH, MacDonald KP, Raggat LJ, Pettit AR, Morrow CA, Waters MJ, Chen P, Woods RG, Thomas GP, St Pierre L, Farah CS, Clarke RA, Brown JA, Lavin MF. Roberts TL, et al. Among authors: luff j. Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):E285-94. doi: 10.1073/pnas.1215696110. Epub 2012 Dec 31. Proc Natl Acad Sci U S A. 2013. PMID: 23277562 Free PMC article.
Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage.
Quek H, Luff J, Cheung K, Kozlov S, Gatei M, Lee CS, Bellingham MC, Noakes PG, Lim YC, Barnett NL, Dingwall S, Wolvetang E, Mashimo T, Roberts TL, Lavin MF. Quek H, et al. Among authors: luff j. J Leukoc Biol. 2017 Apr;101(4):927-947. doi: 10.1189/jlb.4VMA0716-316R. Epub 2016 Nov 28. J Leukoc Biol. 2017. PMID: 27895165
A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype.
Quek H, Luff J, Cheung K, Kozlov S, Gatei M, Lee CS, Bellingham MC, Noakes PG, Lim YC, Barnett NL, Dingwall S, Wolvetang E, Mashimo T, Roberts TL, Lavin MF. Quek H, et al. Among authors: luff j. Hum Mol Genet. 2017 Jan 1;26(1):109-123. doi: 10.1093/hmg/ddw371. Hum Mol Genet. 2017. PMID: 28007901
Regulation of the Atm promoter in vivo.
Gueven N, Fukao T, Luff J, Paterson C, Kay G, Kondo N, Lavin MF. Gueven N, et al. Among authors: luff j. Genes Chromosomes Cancer. 2006 Jan;45(1):61-71. doi: 10.1002/gcc.20267. Genes Chromosomes Cancer. 2006. PMID: 16180236
64 results