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Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage.
Quek H, Luff J, Cheung K, Kozlov S, Gatei M, Lee CS, Bellingham MC, Noakes PG, Lim YC, Barnett NL, Dingwall S, Wolvetang E, Mashimo T, Roberts TL, Lavin MF. Quek H, et al. J Leukoc Biol. 2017 Apr;101(4):927-947. doi: 10.1189/jlb.4VMA0716-316R. Epub 2016 Nov 28. J Leukoc Biol. 2017. PMID: 27895165
PIKKing a way to regulate inflammation.
Quek H, Lim YC, Lavin MF, Roberts TL. Quek H, et al. Immunol Cell Biol. 2018 Jan;96(1):8-20. doi: 10.1111/imcb.1001. Epub 2017 Nov 14. Immunol Cell Biol. 2018. PMID: 29359354 Review.
Simultaneous targeting of DNA replication and homologous recombination in glioblastoma with a polyether ionophore.
Lim YC, Ensbey KS, Offenhäuser C, D'souza RCJ, Cullen JK, Stringer BW, Quek H, Bruce ZC, Kijas A, Cianfanelli V, Mahboubi B, Smith F, Jeffree RL, Wiesmüeller L, Wiegmans AP, Bain A, Lombard FJ, Roberts TL, Khanna KK, Lavin MF, Kim B, Hamerlik P, Johns TG, Coster MJ, Boyd AW, Day BW. Lim YC, et al. Among authors: quek h. Neuro Oncol. 2020 Feb 20;22(2):216-228. doi: 10.1093/neuonc/noz159. Neuro Oncol. 2020. PMID: 31504812 Free PMC article.
ALS monocyte-derived microglia-like cells reveal cytoplasmic TDP-43 accumulation, DNA damage, and cell-specific impairment of phagocytosis associated with disease progression.
Quek H, Cuní-López C, Stewart R, Colletti T, Notaro A, Nguyen TH, Sun Y, Guo CC, Lupton MK, Roberts TL, Lim YC, Oikari LE, La Bella V, White AR. Quek H, et al. J Neuroinflammation. 2022 Feb 28;19(1):58. doi: 10.1186/s12974-022-02421-1. J Neuroinflammation. 2022. PMID: 35227277 Free PMC article.
53 results