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Sphingosine kinase 2 promotes lipotoxicity in pancreatic β-cells and the progression of diabetes.
Song Z, Wang W, Li N, Yan S, Rong K, Lan T, Xia P. Song Z, et al. Among authors: wang w. FASEB J. 2019 Mar;33(3):3636-3646. doi: 10.1096/fj.201801496R. Epub 2018 Nov 19. FASEB J. 2019. PMID: 30452878 Free PMC article.
These findings provide the first evidence, in vitro and in vivo, of a critical role for SK2 in mediating beta-cell lipotoxicity and the progression of diabetes.-Song, Z., Wang, W., Li, N., Yan, S., Rong, K., Lan, T., Xia, P. Sphingosine kinase 2 promotes lipotoxicit …
These findings provide the first evidence, in vitro and in vivo, of a critical role for SK2 in mediating beta-cell lipotoxicity and the prog …
Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2.
Aji G, Huang Y, Ng ML, Wang W, Lan T, Li M, Li Y, Chen Q, Li R, Yan S, Tran C, Burchfield JG, Couttas TA, Chen J, Chung LH, Liu D, Wadham C, Hogg PJ, Gao X, Vadas MA, Gamble JR, Don AS, Xia P, Qi Y. Aji G, et al. Among authors: wang w. Proc Natl Acad Sci U S A. 2020 Sep 29;117(39):24434-24442. doi: 10.1073/pnas.2007856117. Epub 2020 Sep 11. Proc Natl Acad Sci U S A. 2020. PMID: 32917816 Free PMC article.
Role of Sphingosine Kinase in Type 2 Diabetes Mellitus.
Qi Y, Wang W, Song Z, Aji G, Liu XT, Xia P. Qi Y, et al. Among authors: wang w. Front Endocrinol (Lausanne). 2021 Feb 9;11:627076. doi: 10.3389/fendo.2020.627076. eCollection 2020. Front Endocrinol (Lausanne). 2021. PMID: 33633691 Free PMC article. Review.
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