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The Drug Rediscovery protocol facilitates the expanded use of existing anticancer drugs.
van der Velden DL, Hoes LR, van der Wijngaart H, van Berge Henegouwen JM, van Werkhoven E, Roepman P, Schilsky RL, de Leng WWJ, Huitema ADR, Nuijen B, Nederlof PM, van Herpen CML, de Groot DJA, Devriese LA, Hoeben A, de Jonge MJA, Chalabi M, Smit EF, de Langen AJ, Mehra N, Labots M, Kapiteijn E, Sleijfer S, Cuppen E, Verheul HMW, Gelderblom H, Voest EE. van der Velden DL, et al. Among authors: de langen aj, de leng wwj, de groot dja, de jonge mja. Nature. 2019 Oct;574(7776):127-131. doi: 10.1038/s41586-019-1600-x. Epub 2019 Sep 30. Nature. 2019. PMID: 31570881 Clinical Trial.
Intracoronary infusion of allogeneic mesenchymal precursor cells directly after experimental acute myocardial infarction reduces infarct size, abrogates adverse remodeling, and improves cardiac function.
Houtgraaf JH, de Jong R, Kazemi K, de Groot D, van der Spoel TI, Arslan F, Hoefer I, Pasterkamp G, Itescu S, Zijlstra F, Geleijnse ML, Serruys PW, Duckers HJ. Houtgraaf JH, et al. Circ Res. 2013 Jul 5;113(2):153-66. doi: 10.1161/CIRCRESAHA.112.300730. Epub 2013 May 8. Circ Res. 2013. PMID: 23658436
Endothelial glycocalyx dimensions are reduced in growing collateral arteries and modulate leucocyte adhesion in arteriogenesis.
Grundmann S, Schirmer SH, Hekking LH, Post JA, Ionita MG, de Groot D, van Royen N, van den Berg B, Vink H, Moser M, Bode C, de Kleijn D, Pasterkamp G, Piek JJ, Hoefer IE. Grundmann S, et al. J Cell Mol Med. 2009 Sep;13(9B):3463-74. doi: 10.1111/j.1582-4934.2009.00735.x. Epub 2009 Mar 6. J Cell Mol Med. 2009. PMID: 19438808 Free PMC article.
CD26 inhibition enhances perfusion recovery in ApoE-/-mice.
Haverslag RT, de Groot D, Grundmann S, Meder B, Goumans MJ, Pasterkamp G, Hoefer IE, de Kleijn DP. Haverslag RT, et al. Curr Vasc Pharmacol. 2013 Jan;11(1):21-8. Curr Vasc Pharmacol. 2013. PMID: 23391419
68 results