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The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies.
Angus L, Smid M, Wilting SM, van Riet J, Van Hoeck A, Nguyen L, Nik-Zainal S, Steenbruggen TG, Tjan-Heijnen VCG, Labots M, van Riel JMGH, Bloemendal HJ, Steeghs N, Lolkema MP, Voest EE, van de Werken HJG, Jager A, Cuppen E, Sleijfer S, Martens JWM. Angus L, et al. Among authors: nguyen l. Nat Genet. 2019 Oct;51(10):1450-1458. doi: 10.1038/s41588-019-0507-7. Epub 2019 Sep 30. Nat Genet. 2019. PMID: 31570896 Free PMC article.
Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses.
de Witte CJ, Espejo Valle-Inclan J, Hami N, Lõhmussaar K, Kopper O, Vreuls CPH, Jonges GN, van Diest P, Nguyen L, Clevers H, Kloosterman WP, Cuppen E, Snippert HJG, Zweemer RP, Witteveen PO, Stelloo E. de Witte CJ, et al. Among authors: nguyen l. Cell Rep. 2020 Jun 16;31(11):107762. doi: 10.1016/j.celrep.2020.107762. Cell Rep. 2020. PMID: 32553164 Free article.
Precancerous liver diseases do not cause increased mutagenesis in liver stem cells.
Nguyen L, Jager M, Lieshout R, de Ruiter PE, Locati MD, Besselink N, van der Roest B, Janssen R, Boymans S, de Jonge J, IJzermans JNM, Doukas M, Verstegen MMA, van Boxtel R, van der Laan LJW, Cuppen E, Kuijk E. Nguyen L, et al. Commun Biol. 2021 Nov 18;4(1):1301. doi: 10.1038/s42003-021-02839-y. Commun Biol. 2021. PMID: 34795391 Free PMC article.
Functional RECAP (REpair CAPacity) assay identifies homologous recombination deficiency undetected by DNA-based BRCAness tests.
Meijer TG, Nguyen L, Van Hoeck A, Sieuwerts AM, Verkaik NS, Ladan MM, Ruigrok-Ritstier K, van Deurzen CHM, van de Werken HJG, Lips EH, Linn SC, Memari Y, Davies H, Nik-Zainal S, Kanaar R, Martens JWM, Cuppen E, Jager A, van Gent DC. Meijer TG, et al. Among authors: nguyen l. Oncogene. 2022 Jun;41(26):3498-3506. doi: 10.1038/s41388-022-02363-1. Epub 2022 Jun 3. Oncogene. 2022. PMID: 35662281 Free PMC article.
Pan-cancer whole-genome comparison of primary and metastatic solid tumours.
Martínez-Jiménez F, Movasati A, Brunner SR, Nguyen L, Priestley P, Cuppen E, Van Hoeck A. Martínez-Jiménez F, et al. Among authors: nguyen l. Nature. 2023 Jun;618(7964):333-341. doi: 10.1038/s41586-023-06054-z. Epub 2023 May 10. Nature. 2023. PMID: 37165194 Free PMC article.
Liquid biopsy uncovers distinct patterns of DNA methylation and copy number changes in NSCLC patients with different EGFR-TKI resistant mutations.
Nguyen HN, Cao NT, Van Nguyen TC, Le KND, Nguyen DT, Nguyen QT, Nguyen TT, Van Nguyen C, Le HT, Nguyen MT, Nguyen TV, Tran VU, Luong BA, Le LGH, Ho QC, Pham HT, Vo BT, Nguyen LT, Dang AH, Nguyen SD, Do DM, Do TT, Hoang AV, Dinh KT, Phan MD, Giang H, Tran LS. Nguyen HN, et al. Sci Rep. 2021 Aug 12;11(1):16436. doi: 10.1038/s41598-021-95985-6. Sci Rep. 2021. PMID: 34385540 Free PMC article.
5,359 results