Wedge SR - Search Results

1

Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy.

Willoughby CE, Jiang Y, Thomas HD, Willmore E, Kyle S, Wittner A, Phillips N, Zhao Y, Tudhope SJ, Prendergast L, Junge G, Lourenco LM, Finlay MRV, Turner P, Munck JM, Griffin RJ, Rennison T, Pickles J, Cano C, Newell DR, Reeves HL, Ryan AJ, Wedge SR. Willoughby CE, et al. Among authors: wedge sr. J Clin Invest. 2020 Jan 2;130(1):258-271. doi: 10.1172/JCI127483. J Clin Invest. 2020. PMID: 31581151 Free PMC article.

2

Measurement of 5,10-dideaza-5,6,7,8-tetrahydrofolate (lometrexol) in human plasma and urine by high-performance liquid chromatography.

Wedge SR, Laohavinij S, Taylor GA, Newell DR. Wedge SR, et al. J Chromatogr B Biomed Appl. 1995 Jan 20;663(2):327-35. doi: 10.1016/0378-4347(94)00441-7. J Chromatogr B Biomed Appl. 1995. PMID: 7735480 Clinical Trial.

3

Pharmacokinetics of high molecular weight agents.

Cassidy J, Newell DR, Wedge SR, Cummings J. Cassidy J, et al. Among authors: wedge sr. Cancer Surv. 1993;17:315-41. Cancer Surv. 1993. PMID: 8137346 Review.

4

A phase I clinical study of the antipurine antifolate lometrexol (DDATHF) given with oral folic acid.

Laohavinij S, Wedge SR, Lind MJ, Bailey N, Humphreys A, Proctor M, Chapman F, Simmons D, Oakley A, Robson L, Gumbrell L, Taylor GA, Thomas HD, Boddy AV, Newell DR, Calvert AH. Laohavinij S, et al. Among authors: wedge sr. Invest New Drugs. 1996;14(3):325-35. doi: 10.1007/BF00194536. Invest New Drugs. 1996. PMID: 8958188 Clinical Trial.

5

Clinical pharmacokinetics of the antipurine antifolate (6R)-5,10- dideaza-5,6,7,8-tetrahydrofolic acid (Lometrexol) administered with an oral folic acid supplement.

Wedge SR, Laohavinij S, Taylor GA, Boddy A, Calvert AH, Newell DR. Wedge SR, et al. Clin Cancer Res. 1995 Dec;1(12):1479-86. Clin Cancer Res. 1995. PMID: 9815947 Clinical Trial.

6

O6-methylguanine-DNA methyltransferase in pretreatment tumour biopsies as a predictor of response to temozolomide in melanoma.

Middleton MR, Lunn JM, Morris C, Rustin G, Wedge SR, Brampton MH, Lind MJ, Lee SM, Newell DR, Bleehen NM, Newlands ES, Calvert AH, Margison GP, Thatcher N. Middleton MR, et al. Among authors: wedge sr. Br J Cancer. 1998 Nov;78(9):1199-202. doi: 10.1038/bjc.1998.654. Br J Cancer. 1998. PMID: 9820180 Free PMC article. Clinical Trial.

7

ZD6474--a novel inhibitor of VEGFR and EGFR tyrosine kinase activity.

Ryan AJ, Wedge SR. Ryan AJ, et al. Among authors: wedge sr. Br J Cancer. 2005 Jun;92 Suppl 1(Suppl 1):S6-13. doi: 10.1038/sj.bjc.6602603. Br J Cancer. 2005. PMID: 15928657 Free PMC article. Review.

8

Inhibiting vascular endothelial growth factor receptor-2 signaling reduces tumor burden in the ApcMin/+ mouse model of early intestinal cancer.

Goodlad RA, Ryan AJ, Wedge SR, Pyrah IT, Alferez D, Poulsom R, Smith NR, Mandir N, Watkins AJ, Wilkinson RW. Goodlad RA, et al. Among authors: wedge sr. Carcinogenesis. 2006 Oct;27(10):2133-9. doi: 10.1093/carcin/bgl113. Epub 2006 Jun 16. Carcinogenesis. 2006. PMID: 16782971

9

ZD6474, an inhibitor of vascular endothelial growth factor receptor tyrosine kinase, inhibits growth of experimental lung metastasis and production of malignant pleural effusions in a non-small cell lung cancer model.

Matsumori Y, Yano S, Goto H, Nakataki E, Wedge SR, Ryan AJ, Sone S. Matsumori Y, et al. Among authors: wedge sr. Oncol Res. 2006;16(1):15-26. doi: 10.3727/000000006783981260. Oncol Res. 2006. PMID: 16783964

10

Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in Apc(Min/+) mice.

Alferez D, Wilkinson RW, Watkins J, Poulsom R, Mandir N, Wedge SR, Pyrah IT, Smith NR, Jackson L, Ryan AJ, Goodlad RA. Alferez D, et al. Among authors: wedge sr. Mol Cancer Ther. 2008 Mar;7(3):590-8. doi: 10.1158/1535-7163.MCT-07-0433. Mol Cancer Ther. 2008. PMID: 18347145

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