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The Outcome of TGFβ Antagonism in Metastatic Breast Cancer Models In Vivo Reflects a Complex Balance between Tumor-Suppressive and Proprogression Activities of TGFβ.
Yang Y, Yang HH, Tang B, Wu AML, Flanders KC, Moshkovich N, Weinberg DS, Welsh MA, Weng J, Ochoa HJ, Hu TY, Herrmann MA, Chen J, Edmondson EF, Simpson RM, Liu F, Liu H, Lee MP, Wakefield LM. Yang Y, et al. Among authors: wakefield lm. Clin Cancer Res. 2020 Feb 1;26(3):643-656. doi: 10.1158/1078-0432.CCR-19-2370. Epub 2019 Oct 3. Clin Cancer Res. 2020. PMID: 31582516 Free PMC article.
Biological responses to TGF-β in the mammary epithelium show a complex dependency on Smad3 gene dosage with important implications for tumor progression.
Kohn EA, Yang YA, Du Z, Nagano Y, Van Schyndle CM, Herrmann MA, Heldman M, Chen JQ, Stuelten CH, Flanders KC, Wakefield LM. Kohn EA, et al. Among authors: wakefield lm. Mol Cancer Res. 2012 Oct;10(10):1389-99. doi: 10.1158/1541-7786.MCR-12-0136-T. Epub 2012 Aug 9. Mol Cancer Res. 2012. PMID: 22878587 Free PMC article.
Aging and CNS Myeloid Cell Depletion Attenuate Breast Cancer Brain Metastasis.
Wu AML, Gossa S, Samala R, Chung MA, Gril B, Yang HH, Thorsheim HR, Tran AD, Wei D, Taner E, Isanogle K, Yang Y, Dolan EL, Robinson C, Difilippantonio S, Lee MP, Khan I, Smith QR, McGavern DB, Wakefield LM, Steeg PS. Wu AML, et al. Among authors: wakefield lm. Clin Cancer Res. 2021 Aug 1;27(15):4422-4434. doi: 10.1158/1078-0432.CCR-21-1549. Epub 2021 Jun 3. Clin Cancer Res. 2021. PMID: 34083229 Free PMC article.
Transforming growth factor-beta can suppress tumorigenesis through effects on the putative cancer stem or early progenitor cell and committed progeny in a breast cancer xenograft model.
Tang B, Yoo N, Vu M, Mamura M, Nam JS, Ooshima A, Du Z, Desprez PY, Anver MR, Michalowska AM, Shih J, Parks WT, Wakefield LM. Tang B, et al. Among authors: wakefield lm. Cancer Res. 2007 Sep 15;67(18):8643-52. doi: 10.1158/0008-5472.CAN-07-0982. Cancer Res. 2007. PMID: 17875704 Free PMC article.
Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway.
Bian Y, Terse A, Du J, Hall B, Molinolo A, Zhang P, Chen W, Flanders KC, Gutkind JS, Wakefield LM, Kulkarni AB. Bian Y, et al. Among authors: wakefield lm. Cancer Res. 2009 Jul 15;69(14):5918-26. doi: 10.1158/0008-5472.CAN-08-4623. Epub 2009 Jul 7. Cancer Res. 2009. PMID: 19584284 Free PMC article.
Identification of novel gene amplifications in breast cancer and coexistence of gene amplification with an activating mutation of PIK3CA.
Kadota M, Sato M, Duncan B, Ooshima A, Yang HH, Diaz-Meyer N, Gere S, Kageyama S, Fukuoka J, Nagata T, Tsukada K, Dunn BK, Wakefield LM, Lee MP. Kadota M, et al. Among authors: wakefield lm. Cancer Res. 2009 Sep 15;69(18):7357-65. doi: 10.1158/0008-5472.CAN-09-0064. Epub 2009 Aug 25. Cancer Res. 2009. PMID: 19706770 Free PMC article.
153 results