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Shear-stress sensing by PIEZO1 regulates tendon stiffness in rodents and influences jumping performance in humans.
Passini FS, Jaeger PK, Saab AS, Hanlon S, Chittim NA, Arlt MJ, Ferrari KD, Haenni D, Caprara S, Bollhalder M, Niederöst B, Horvath AN, Götschi T, Ma S, Passini-Tall B, Fucentese SF, Blache U, Silván U, Weber B, Silbernagel KG, Snedeker JG. Passini FS, et al. Among authors: horvath an. Nat Biomed Eng. 2021 Dec;5(12):1457-1471. doi: 10.1038/s41551-021-00716-x. Epub 2021 May 24. Nat Biomed Eng. 2021. PMID: 34031557 Free PMC article.
GPR180 is a component of TGFβ signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1.
Balazova L, Balaz M, Horvath C, Horváth Á, Moser C, Kovanicova Z, Ghosh A, Ghoshdastider U, Efthymiou V, Kiehlmann E, Sun W, Dong H, Ding L, Amri EZ, Nuutila P, Virtanen KA, Niemi T, Ukropcova B, Ukropec J, Pelczar P, Lamla T, Hamilton B, Neubauer H, Wolfrum C. Balazova L, et al. Nat Commun. 2021 Dec 8;12(1):7144. doi: 10.1038/s41467-021-27442-x. Nat Commun. 2021. PMID: 34880217 Free PMC article.