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No evidence of P. falciparum K13 artemisinin conferring mutations over a 24-year analysis in Coastal Kenya, but a near complete reversion to chloroquine wild type parasites.
Wamae K, Okanda D, Ndwiga L, Osoti V, Kimenyi KM, Abdi AI, Bejon P, Sutherland C, Ochola-Oyier LI. Wamae K, et al. Among authors: sutherland c. Antimicrob Agents Chemother. 2019 Sep 9;63(12):e01067-19. doi: 10.1128/AAC.01067-19. Epub 2019 Oct 7. Antimicrob Agents Chemother. 2019. PMID: 31591113 Free PMC article.
Amodiaquine and artemether-lumefantrine select distinct alleles of the Plasmodium falciparum mdr1 gene in Tanzanian children treated for uncomplicated malaria.
Humphreys GS, Merinopoulos I, Ahmed J, Whitty CJ, Mutabingwa TK, Sutherland CJ, Hallett RL. Humphreys GS, et al. Among authors: sutherland cj. Antimicrob Agents Chemother. 2007 Mar;51(3):991-7. doi: 10.1128/AAC.00875-06. Epub 2006 Dec 28. Antimicrob Agents Chemother. 2007. PMID: 17194834 Free PMC article. Clinical Trial.
Increased pfmdr1 copy number and sequence polymorphisms in Plasmodium falciparum isolates from Sudanese malaria patients treated with artemether-lumefantrine.
Gadalla NB, Adam I, Elzaki SE, Bashir S, Mukhtar I, Oguike M, Gadalla A, Mansour F, Warhurst D, El-Sayed BB, Sutherland CJ. Gadalla NB, et al. Antimicrob Agents Chemother. 2011 Nov;55(11):5408-11. doi: 10.1128/AAC.05102-11. Epub 2011 Sep 6. Antimicrob Agents Chemother. 2011. PMID: 21896916 Free PMC article.
The polymorphic linker domain of pfmdr1 is associated with resistance-conferring mutations in Plasmodium falciparum populations from East and West Africa.
Okombo J, Zongo I, Gadalla N, Bousema T, Beshir KB, Roper C, Hallett R, Ochola-Oyier LI, Sutherland CJ. Okombo J, et al. Among authors: sutherland cj. Antimicrob Agents Chemother. 2013 Sep;57(9):4595-8. doi: 10.1128/AAC.00455-13. Epub 2013 Jul 8. Antimicrob Agents Chemother. 2013. PMID: 23836177 Free PMC article.
876 results