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Page 1
A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis.
van Delft MF, Chappaz S, Khakham Y, Bui CT, Debrincat MA, Lowes KN, Brouwer JM, Grohmann C, Sharp PP, Dagley LF, Li L, McArthur K, Luo MX, Chin HS, Fairlie WD, Lee EF, Segal D, Duflocq S, Lessene R, Bernard S, Peilleron L, Nguyen T, Miles C, Wan SS, Lane RM, Wardak A, Lackovic K, Colman PM, Sandow JJ, Webb AI, Czabotar PE, Dewson G, Watson KG, Huang DCS, Lessene G, Kile BT. van Delft MF, et al. Among authors: lane rm. Nat Chem Biol. 2019 Nov;15(11):1057-1066. doi: 10.1038/s41589-019-0365-8. Epub 2019 Oct 7. Nat Chem Biol. 2019. PMID: 31591564
Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets.
Josefsson EC, James C, Henley KJ, Debrincat MA, Rogers KL, Dowling MR, White MJ, Kruse EA, Lane RM, Ellis S, Nurden P, Mason KD, O'Reilly LA, Roberts AW, Metcalf D, Huang DC, Kile BT. Josefsson EC, et al. Among authors: lane rm. J Exp Med. 2011 Sep 26;208(10):2017-31. doi: 10.1084/jem.20110750. Epub 2011 Sep 12. J Exp Med. 2011. PMID: 21911424 Free PMC article.
Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival.
Debrincat MA, Josefsson EC, James C, Henley KJ, Ellis S, Lebois M, Betterman KL, Lane RM, Rogers KL, White MJ, Roberts AW, Harvey NL, Metcalf D, Kile BT. Debrincat MA, et al. Among authors: lane rm. Blood. 2012 Jun 14;119(24):5850-8. doi: 10.1182/blood-2011-12-398834. Epub 2012 Feb 28. Blood. 2012. PMID: 22374700 Free article.
Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production.
White MJ, McArthur K, Metcalf D, Lane RM, Cambier JC, Herold MJ, van Delft MF, Bedoui S, Lessene G, Ritchie ME, Huang DC, Kile BT. White MJ, et al. Among authors: lane rm. Cell. 2014 Dec 18;159(7):1549-62. doi: 10.1016/j.cell.2014.11.036. Cell. 2014. PMID: 25525874 Free PMC article.
BCL-2 is dispensable for thrombopoiesis and platelet survival.
Debrincat MA, Pleines I, Lebois M, Lane RM, Holmes ML, Corbin J, Vandenberg CJ, Alexander WS, Ng AP, Strasser A, Bouillet P, Sola-Visner M, Kile BT, Josefsson EC. Debrincat MA, et al. Among authors: lane rm. Cell Death Dis. 2015 Apr 16;6(4):e1721. doi: 10.1038/cddis.2015.97. Cell Death Dis. 2015. PMID: 25880088 Free PMC article.
IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome.
Murphy AJ, Kraakman MJ, Kammoun HL, Dragoljevic D, Lee MK, Lawlor KE, Wentworth JM, Vasanthakumar A, Gerlic M, Whitehead LW, DiRago L, Cengia L, Lane RM, Metcalf D, Vince JE, Harrison LC, Kallies A, Kile BT, Croker BA, Febbraio MA, Masters SL. Murphy AJ, et al. Among authors: lane rm. Cell Metab. 2016 Jan 12;23(1):155-64. doi: 10.1016/j.cmet.2015.09.024. Epub 2015 Oct 22. Cell Metab. 2016. PMID: 26603191 Free article.
Physiological restraint of Bak by Bcl-xL is essential for cell survival.
Lee EF, Grabow S, Chappaz S, Dewson G, Hockings C, Kluck RM, Debrincat MA, Gray DH, Witkowski MT, Evangelista M, Pettikiriarachchi A, Bouillet P, Lane RM, Czabotar PE, Colman PM, Smith BJ, Kile BT, Fairlie WD. Lee EF, et al. Among authors: lane rm. Genes Dev. 2016 May 15;30(10):1240-50. doi: 10.1101/gad.279414.116. Epub 2016 May 19. Genes Dev. 2016. PMID: 27198225 Free PMC article.
BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis.
McArthur K, Whitehead LW, Heddleston JM, Li L, Padman BS, Oorschot V, Geoghegan ND, Chappaz S, Davidson S, San Chin H, Lane RM, Dramicanin M, Saunders TL, Sugiana C, Lessene R, Osellame LD, Chew TL, Dewson G, Lazarou M, Ramm G, Lessene G, Ryan MT, Rogers KL, van Delft MF, Kile BT. McArthur K, et al. Among authors: lane rm. Science. 2018 Feb 23;359(6378):eaao6047. doi: 10.1126/science.aao6047. Science. 2018. PMID: 29472455
Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion.
Pleines I, Lebois M, Gangatirkar P, Au AE, Lane RM, Henley KJ, Kauppi M, Corbin J, Cannon P, Bernardini J, Alwis I, Jarman KE, Ellis S, Metcalf D, Jackson SP, Schoenwaelder SM, Kile BT, Josefsson EC. Pleines I, et al. Among authors: lane rm. Blood. 2018 Jul 12;132(2):197-209. doi: 10.1182/blood-2017-11-816355. Epub 2018 May 21. Blood. 2018. PMID: 29784641 Free article.
68 results