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Discovery of a Novel Cabazitaxel Nanoparticle-Drug Conjugate (CRLX522) with Improved Pharmacokinetic Properties and Anticancer Effects Using a β-Cyclodextrin-PEG Copolymer Based Delivery Platform.
Metcalf CA 3rd, Svenson S, Hwang J, Tripathi S, Gangal G, Kabir S, Lazarus D, Cole R, Sweryda-Krawiec B, Shum P, Brown D, Case RI, van der Poll D, Rohde E, Harlfinger S, Teng CH, Eliasof S. Metcalf CA 3rd, et al. Among authors: lazarus d. J Med Chem. 2019 Nov 14;62(21):9541-9559. doi: 10.1021/acs.jmedchem.9b00892. Epub 2019 Oct 24. J Med Chem. 2019. PMID: 31593466
Correlating preclinical animal studies and human clinical trials of a multifunctional, polymeric nanoparticle.
Eliasof S, Lazarus D, Peters CG, Case RI, Cole RO, Hwang J, Schluep T, Chao J, Lin J, Yen Y, Han H, Wiley DT, Zuckerman JE, Davis ME. Eliasof S, et al. Among authors: lazarus d. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15127-32. doi: 10.1073/pnas.1309566110. Epub 2013 Aug 26. Proc Natl Acad Sci U S A. 2013. PMID: 23980155 Free PMC article.
Tumor Selective Silencing Using an RNAi-Conjugated Polymeric Nanopharmaceutical.
Svenson S, Case RI, Cole RO, Hwang J, Kabir SR, Lazarus D, Lim Soo P, Ng PS, Peters C, Shum P, Sweryda-Krawiec B, Tripathi S, van der Poll D, Eliasof S. Svenson S, et al. Among authors: lazarus d. Mol Pharm. 2016 Mar 7;13(3):737-47. doi: 10.1021/acs.molpharmaceut.5b00608. Epub 2016 Feb 2. Mol Pharm. 2016. PMID: 26835715
CRLX101, an investigational camptothecin-containing nanoparticle-drug conjugate, targets cancer stem cells and impedes resistance to antiangiogenic therapy in mouse models of breast cancer.
Conley SJ, Baker TL, Burnett JP, Theisen RL, Lazarus D, Peters CG, Clouthier SG, Eliasof S, Wicha MS. Conley SJ, et al. Among authors: lazarus d. Breast Cancer Res Treat. 2015 Apr;150(3):559-67. doi: 10.1007/s10549-015-3349-8. Epub 2015 Apr 2. Breast Cancer Res Treat. 2015. PMID: 25833208
181 results