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The Novel Glutamine Antagonist Prodrug JHU395 Has Antitumor Activity in Malignant Peripheral Nerve Sheath Tumor.
Lemberg KM, Zhao L, Wu Y, Veeravalli V, Alt J, Aguilar JMH, Dash RP, Lam J, Tenora L, Rodriguez C, Nedelcovych MT, Brayton C, Majer P, Blakeley JO, Rais R, Slusher BS. Lemberg KM, et al. Among authors: majer p. Mol Cancer Ther. 2020 Feb;19(2):397-408. doi: 10.1158/1535-7163.MCT-19-0319. Epub 2019 Oct 8. Mol Cancer Ther. 2020. PMID: 31594823 Free PMC article.
Glutamate carboxypeptidase II inhibition as a novel therapeutic target.
Rojas C, Thomas AG, Majer P, Tsukamoto T, Lu XM, Vornov JJ, Wozniak KM, Slusher BS. Rojas C, et al. Among authors: majer p. Adv Exp Med Biol. 2003;524:205-13. doi: 10.1007/0-306-47920-6_25. Adv Exp Med Biol. 2003. PMID: 12675241 Review. No abstract available.
Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor.
Majer P, Jackson PF, Delahanty G, Grella BS, Ko YS, Li W, Liu Q, Maclin KM, Poláková J, Shaffer KA, Stoermer D, Vitharana D, Wang EY, Zakrzewski A, Rojas C, Slusher BS, Wozniak KM, Burak E, Limsakun T, Tsukamoto T. Majer P, et al. J Med Chem. 2003 May 8;46(10):1989-96. doi: 10.1021/jm020515w. J Med Chem. 2003. PMID: 12723961
Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models.
Ghadge GD, Slusher BS, Bodner A, Canto MD, Wozniak K, Thomas AG, Rojas C, Tsukamoto T, Majer P, Miller RJ, Monti AL, Roos RP. Ghadge GD, et al. Among authors: majer p. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9554-9. doi: 10.1073/pnas.1530168100. Epub 2003 Jul 22. Proc Natl Acad Sci U S A. 2003. PMID: 12876198 Free PMC article.
Enantiospecificity of glutamate carboxypeptidase II inhibition.
Tsukamoto T, Majer P, Vitharana D, Ni C, Hin B, Lu XC, Thomas AG, Wozniak KM, Calvin DC, Wu Y, Slusher BS, Scarpetti D, Bonneville GW. Tsukamoto T, et al. Among authors: majer p. J Med Chem. 2005 Apr 7;48(7):2319-24. doi: 10.1021/jm049258g. J Med Chem. 2005. PMID: 15801825
123 results